IL-1β+3954 genetic polymorphism association with generalized aggressive periodontitis in Khorasan-Iran Province

Arab, H. R. and Tavakkol-Afshari, J. and Radvar, M. and Moeintaghavi, A. and Sargolzaei, N. and Rigi, A. and Shirkhani, M. (2007) IL-1β+3954 genetic polymorphism association with generalized aggressive periodontitis in Khorasan-Iran Province. Journal of Medical Sciences, 7 (2). pp. 222-227.

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Abstract

The aim of this study was to investigate the relationship between IL-1β+3954 gene polymorphism and Generalized Aggressive Periodontitis (GAP). This study included 25 patients diagnosed as GAP from Khorasan province and 18 periodontally healthy controls. They were referred to Periodontology Department of Mashad Dental School. Extracted DNA from peripheral blood was evaluated by PCR-RFLP method. Data were analyzed using Chi-square test, Fisher's exact test and two sample t-tests. There was no significant association between IL-1β +3954 genotype and GAP disease (p = 0.419). There was no significant association between IL-1β+3954 alleles and GAP disease either (p = 0.370). However, there was some trend for greater of 1.1 genotype and allele 1 prevalence among GAP patients compared to controls (56 and 44.4 for 1.1 genotype among GAP and control patients respectively, 78 and 69.4 for allele 1 frequency among GAP and controls, respectively). The frequencies of 1.1 genotype and allele 1 in the population of this study were 51.2 and 74.4, respectively. The lack of any association between IL-1β +3954 polymorphism and GAP, in the population presented here, brings into doubt the usefulness of this gene as a marker of susceptibility to GAP. To elucidate this relationship, more research is necessary.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Moeintaghavi, A.; Department of Periodontics, Faculty of Dentistry and Dental Research Center, Mashad University Medical Sciences, P.O. Box 984 Vakilabad Blvd., 91735 Mashhad, Iran
Uncontrolled Keywords: Gene polymorphism IL-1 Periodontitis genomic DNA interleukin 1beta adult allele article blood sampling clinical article controlled study disease association DNA determination DNA polymorphism female gene sequence genetic susceptibility genotype human Iran male marker gene periodontal disease polymerase chain reaction restriction fragment length polymorphism
Subjects: WU Dentistry. Oral surgery
QW Microbiology and Immunology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 29 Apr 2020 04:59
Last Modified: 29 Apr 2020 04:59
URI: http://eprints.mums.ac.ir/id/eprint/16927

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