Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients

Bagheri, R. and Haghi, S. Z. and Rahim, M. B. and Attaran, D. and Toosi, M. S. (2011) Malignant pleural mesothelioma: Clinicopathologic and survival characteristic in a consecutive series of 40 patients. Annals of Thoracic and Cardiovascular Surgery, 17 (2). pp. 130-136.

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Abstract

Introduction: Pleural malignant mesothelioma is an uncommon but extremely invasive tumor which originates from mesothelial cells and usually occurs after prolonged exposure to asbestos. Different types of surgical and oncological therapeutic methods have been used resulting in various outcomes. The aim of this study was to evaluate, clinicopathologically, 40 patients with pleural malignant mesothelioma and the main factors influencing their prognosis. Methods: In this study, 40 patients with a definitive diagnosis, who had been followed up for at least 3 years were studied according to these: epidemiologic factors, stage and pathological types, treatment method and complications, and by using factors that influence patients survival, we evaluated them statistically. Results: The M/F ratio was l3/1 with an average age of 55 years. Chest pain was the most common symptom. In 55 of patients, the lesions were localized in the left site and most were in Buchart stage I or II. The epithelial form was the most common pathological pattern (62.5). 47.5 of patients only received radiotherapy and chemotherapy. Of patients who underwent decortication and pleurectomy with adjuvant therapy, extrapleural was performed in 20 of patients, and pneumonectomy, in 17.5; and 15 refused any type of treatment. One patient died from the surgery. The most common surgical complication was wound infection. The average survival was 10.5 months, and the main factors influencing the survival were physiologic status, pathological form of disease, stage of disease and the pattern of pleural involvement. Conclusion: Because of the low survival after multimodality invasive treatments in mesothelioma, aggressive therapeutic methods were recommended in patients with good physiological status and early clinical stage with a good pathology type. © 2011 The Editorial Committee of Annals of Thoracic and Cardiovascular Surgery.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 Correspondence Address: Bagheri, R.; Endoscopic and Minimal Invasive Research Center, Ghaem Hospital, Ahmadabad Street, Mashhad, Iran; email: Bagherir@mums.ac.ir
Uncontrolled Keywords: Diagnosis Malignant mesthelioma Pleura Treatment
Subjects: WF Respiratory System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 30 Apr 2020 06:22
Last Modified: 30 Apr 2020 06:22
URI: http://eprints.mums.ac.ir/id/eprint/16934

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