Evaluation of the effect of formic acid and sodium formate on hair reduction in rat

Banihashemi, M. and Rad, A. K. and Yazdi, S. A. T. and Rakhshande, H. and Ghoyonlo, V. M. and Zabihi, Z. and Yousefzadeh, H. (2011) Evaluation of the effect of formic acid and sodium formate on hair reduction in rat. Clinical, Cosmetic and Investigational Dermatology, 4. pp. 69-72.

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Abstract

Hirsutism is a common problem in dermatology that imposes high socioeconomical costs on medical care. Consequently, researchers are actively searching for cheaper and safer methods for therapeutic treatment. The objective of the present study is to evaluate formic oil, enriched from formic acid, for the removal of unwanted hair. In this study, 32 female rats (150–200 g) were randomly divided into four groups and maintained with normal water and food availability. A patch of skin was shaved on each rat for application of test solutions. The control group was treated with local once-daily applications of normal saline. The formic acid, acetic acid, and sodium formate groups were treated with once-daily applications of formic acid (pH 5.5), acetic acid (pH 5.5), or sodium formate, respectively. After 2 weeks, horizontally cut sample biopsies were removed, and the numbers of hair follicles were counted under high field microscopy by a specialist blinded to the treatments. Kolmogorov–Smirnov test results indicated a nonparametric distribution for the rat groups. ANOVA analysis indicated no statistically significant differences between groups (P< 0.05). There weren’t any side effects or evidence for toxicity during the study period. However, hair follicle counts showed a descending order of control, acetic acid, formic acid, and sodium formate. Although the sodium formate group had the lowest hair follicle numbers, the difference was not statistically significant (P> 0.05). Formic acid was not effective in reducing hair follicle numbers in rats. © 2011 Banihashemi et al.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Yousefzadeh, H.; Young Researchers Club, Islamic Azad University, Mashhad BranchIran; email: hadisyousefzadeh@yahoo.com
Uncontrolled Keywords: Hair follicles Hair removal Hirsutism acetic acid formic acid sodium chloride sodium derivative sodium formate unclassified drug water animal experiment animal model animal tissue Article clinical evaluation controlled study drug efficacy female food availability hair follicle microscopy nonhuman rat skin skin biopsy treatment duration
Subjects: WR Dermatology
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 26 Apr 2020 17:59
Last Modified: 26 Apr 2020 17:59
URI: http://eprints.mums.ac.ir/id/eprint/16939

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