Zataria multiflora Boiss and carvacrol affect β2- adrenoceptors of guinea pig trachea

Boskabady, M. H. and Kaveh, M. and Eftekhar, N. and Nemati, A. (2011) Zataria multiflora Boiss and carvacrol affect β2- adrenoceptors of guinea pig trachea. Evidence-based Complementary and Alternative Medicine, 2011.

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Abstract

The stimulatory effect of Zataria multiflora Boiss (Labiatae) and carvacrol on β-adrenoceptors was examined on guinea pig trachea. The effects of three concentrations of aqueous-ethanolic extract, carvacrol, and propranolol (β-receptor antagonist) on β-adrenoceptors were tested in nonincubated (group 1, n = 8) and incubated tracheal chains with 1μM chlorpheniramine (histamine H1 receptor antagonist) (group 2, n = 5). Isoprenaline (β-receptor agonist) curves obtained in the presence of all concentrations of the extract and carvacrol showed leftward shifts compared with that of saline in both groups. In both groups, the EC50 (the effective concentration of isoprenaline, causing 50 of maximum response) obtained in the presence of all concentrations of the extract and carvacrol was significantly lower compared to that of saline (P < . 01 to P <. 001). All values of (CR-1: (EC50 in the presence of active substances/EC50 obtained in the presence of saline)-1) obtained in the presence of concentrations of the extract and carvacrol in both groups were negative and significantly different from that of propranolol (P < . 001 for all cases). The results indicated a stimulatory effect of Zataria multiflora Boiss extract on β2-adrenoceptors which is perhaps due to its constituent, carvacrol. Copyright © 2011 Mohammad Hossein Boskabady et al.

Item Type: Article
Additional Information: Cited By :33 Export Date: 16 February 2020 Correspondence Address: Boskabady, M. H.; Department of Physiology and Pharmaceutical Research Centre, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran; email: boskabadymh@mums.ac.ir
Uncontrolled Keywords: beta 2 adrenergic receptor carvacrol chlorpheniramine isoprenaline plant extract propranolol unclassified drug Zataria multiflora extract animal tissue article concentration response controlled study drug effect drug mechanism guinea pig nonhuman priority journal trachea Zataria multiflora
Subjects: QT physiology
QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 04 May 2020 04:23
Last Modified: 04 May 2020 04:23
URI: http://eprints.mums.ac.ir/id/eprint/16948

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