The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorders

Delavarian, Z. and Javadzade-Bolouri, A. and Dalirsani, Z. and Arshadi, H. R. and Toofani-Asl, H. (2010) The evaluation of psychiatric drug therapy on oral lichen planus patients with psychiatric disorders. Medicina Oral, Patologia Oral y Cirugia Bucal, 15 (2). e322-e327.

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Objectives: Current treatments of oral lichen planus are palliative, not curative. Because psychiatric disorders significantly influence the development and severity of oral lichen planus, the use of psychiatric drug therapy may be an adjunct in treatment. The purpose of this study was to determine the efficacy of drug therapy of psychiatric disorders in oral lichen planus. Study design: Our controlled clinical study consisted of forty-six patients with oral lichen planus and psychiatric disorders who were randomly divided into two groups. Both groups were given topical corticosteroids and the study group received additional psychiatric drug therapy. Patients were monitored for a period of 6 months. Response to treatment was evaluated in each group and was compared with the other group using Mann-Whitney tests. We evaluated the correlation between psychiatric disorders and the recovery of oral lesions using Spearman's correlation coefficient analysis. Results: Decrease in the size of the lesions was significantly greater in the study group after six months, but this difference was not significant in relationship to the pain experienced and the kind of lesion. Spearman's correlation coefficient analysis demonstrated that, in the sixth month, there was a significant and direct relationship between recovery from the psychiatric disorders and response to treatment of OLP lesions, particularly as it pertained to the kind of lesion. Conclusion: The present study indicates that the combination of psychiatric drug therapy and routine treatment methods were effective in reducing the size of the lesions, but did not have any significant effect on the symptoms. © Medicina Oral S. L.

Item Type: Article
Additional Information: Cited By :8 Export Date: 16 February 2020 Correspondence Address: Dalirsani, Z.; Mashhad University of Medical Sciences, Department of Oral Medicine, Mashhad Dental School, Mashhad, Iran; email:
Uncontrolled Keywords: Anxiety disorders Drug therapy Lichen planus Oral Psychiatric disorders nystatin psychotropic agent triamcinolone article clinical trial controlled clinical trial controlled study drug efficacy human major clinical study mental disease pain assessment randomized controlled trial treatment response Humans Lichen Planus, Oral Mental Disorders Single-Blind Method
Subjects: WM Psychiatry
WU Dentistry. Oral surgery
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 04 May 2020 05:44
Last Modified: 04 May 2020 05:44

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