Cytotoxic evaluations of Iranian conifers on cancer ells

Emami, S. A. and Sadeghi-Aliabadi, H. and Saeidi, M. and Jafarian, A. (2005) Cytotoxic evaluations of Iranian conifers on cancer ells. Pharmaceutical Biology, 43 (4). pp. 299-304.

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Abstract

In this study, branchlets, fruit, or bark of Taxus baccata L. as well as branchlets or fruits of two other species of Iranian conifers, namely, Platycladus orientalis France and Cupressus sempervirens L. var. horizentalis (Mill) Gunde were collected, identified, and the cytotoxic effects of hydroalcoholic extracts on three human tumor cell lines were determined. Different concentrations of extracts were added to cultured cells and incubated for 72 h. Cell survival was evaluated using the MTT assay. Extracts from bark of female Taxus baccata showed inhibitory activities against Hela cells. The extracts of the branchlets of male and female T. baccata as well as obtained extract from fruits of P. orientalis showed inhibitory activities against MDA-MB-468 cells, whereas the extracts of branchlets of female T. baccata showed inhibitory activities against KB cells. In conclusion, obtained extract from bark of T. baccata showed comparable cytotoxic effect to doxorubicin against Hela cells. © 2005 Taylor & Francis Ltd.

Item Type: Article
Additional Information: Cited By :10 Export Date: 16 February 2020 CODEN: PHBIF Correspondence Address: Sadeghi-Aliabadi, H.; Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran; email: sadeghi@pharm.mui.ac.ir
Uncontrolled Keywords: Cupressus Cytotoxicity MTT assay Platycladus Taxus 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide antineoplastic agent Cupressus sempervirens extract cytotoxic agent doxorubicin plant extract Platycladus orientalis extract Taxus baccata extract unclassified drug antineoplastic activity article bark cancer cell culture cell assay cell strain KB cell strain MDA MB 468 cell survival conifer controlled study cupressus sempervirens dose response drug cytotoxicity drug effect drug identification drug isolation drug screening fruit HeLa cell human human cell Iran nonhuman Platycladus orientalis Taxus baccata Coniferophyta
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 22 Apr 2020 07:19
Last Modified: 22 Apr 2020 07:19
URI: http://eprints.mums.ac.ir/id/eprint/16967

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