Rapid urease test, touch cytology and histopathologic assessment in determining infection by Helicobacter pylori in outpatient setting

Fakhrjou, A. and Somi, M. H. and Fattahi, E. and Koohbanam, S. S. and Shadravan, S. (2011) Rapid urease test, touch cytology and histopathologic assessment in determining infection by Helicobacter pylori in outpatient setting. Pakistan Journal of Biological Sciences, 14 (12). pp. 698-702.

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Abstract

Helicobacter pylori (HP) is a common cause of gastric infection with serious consequences which is detected by different methods. This study aimed at comparing the diagnostic value of Rapid Urease Test (RUT), Touch Cytology (TC) and histopathologic assessment in outpatients setting. In this cross-sectional study, 51 candidates for upper gastrointestinal endoscopy were recruited in Tabriz Imam Khomeini Teaching Centre in a 24 month period of time. Three biopsy specimens were obtained from gastric antrum during endoscopic intervention. The RUT, TC and histopathologic assessment were performed on each biopsy specimen in each patient. Definite infection by HP was considered when at least 2 out of 3 tests indicated presence of infection. Fifty one patients, 29 females and 22 males with a mean age of 40.10±12.54 (range: 18-72) years enrolled in this study. Infection by HP was definite in 41 cases (80.4). The infection rates by RUT, TC and histopathologic examination were 82.4, 82.4 and 76.5, respectively. The sensitivity, specificity and accuracy of RUT, TC and histopathologic assessment were 92.7, 60 and 66.75; 100, 90 and 98 and 95.1, 100 and 96.1, respectively. There were significant agreements between outcomes of the three methods in diagnosis of infection by HP. In conclusion, TC was the most sensitive and histopathologic assessment was the most specific method in diagnosis of infection by HP in outpatient setting. The diagnostic value of RUT was rather low in this regard. © 2011 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Cited By :6 Export Date: 16 February 2020 Correspondence Address: Fakhrjou, A.; Department of Pathology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
Uncontrolled Keywords: Endoscopy Helicobacter pylori Histopathologic assessment Rapid urease test Touch cytology diagnostic agent urease adult article biopsy breath analysis cross-sectional study cytology digestive tract endoscopy enzymology female Helicobacter infection human male methodology middle aged outpatient pathology Breath Tests Cross-Sectional Studies Cytological Techniques Endoscopy, Digestive System Helicobacter Infections Humans Outpatients
Subjects: QY Clinical Pathology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 03 May 2020 03:51
Last Modified: 03 May 2020 03:51
URI: http://eprints.mums.ac.ir/id/eprint/16970

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