Plasma brain natriuretic peptide (BNP) as an indicator of left ventricular function, early outcome and mechanical complications after acute myocardial infarction

Fazlinezhad, A. and Khadem Rezaeian, M. and Yousefzadeh, H. and Ghaffarzadegan, K. and Khajedaluee, M. (2011) Plasma brain natriuretic peptide (BNP) as an indicator of left ventricular function, early outcome and mechanical complications after acute myocardial infarction. Clinical Medicine Insights: Cardiology, 5. pp. 77-83.

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Abstract

Aims: This study investigated the prognostic value of B type natriuretic peptide (BNP) in acute myocardial infarction (AMI) patients and its relation with left ventricular function and post-myocardial infarction complications. Methods: In this cross-sectional study, plasma BNP level was measured for 42 consecutive patients (mean± SD: 61.6± 10.85 years old) with acute ST elevation myocardial infarction (MI) and 42 healthy, age and gender matched subjects. Result: BNP level in AMI patients were significantly higher than control group (P < 0.001). Regarding to infarct location, the highest BNP level measured in inferoposterior MI (BNP=4436.63± 6188.159 pg/ml) and the lowest one indicated in standalone inferior MI (BNP=598.83± 309.867 pg/ml (P=0.071). There was significant reverse relation between BNP and EF (P=0.006, OR=-0.47) and a significant relationship between BNP and killip classification (P=0.036). There was no significant relation between diastolic and rightventricular function and BNP level (P=0.61, P=0.21). The highest BNP level was detected in LV septal rupture and false aneurysm (P=0.02) and in ventricular tachycardia, but without significant relationship (P=0.25). Conclusion: After the onset of AMI, BNP blood level can be used as an important predictor for left ventricular dysfunction, killip classification, early mechanical complications and cardiac death. © the author(s), publisher and licensee Libertas Academica Ltd.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 Correspondence Address: Fazlinezhad, A.; Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran; email: hadisyousefazdeh@yahoo.com
Uncontrolled Keywords: Acute myocardial infarction Brain natriuretic peptide Mechanical heart complications Systolic dysfunction acute heart infarction adult article brain natriuretic peptide blood level clinical article controlled study cross-sectional study diastolic dysfunction false aneurysm female first degree atrioventricular block heart death heart ejection fraction heart left ventricle failure heart left ventricle function heart right ventricle function heart ventricle extrasystole heart ventricle fibrillation heart ventricle septum rupture heart ventricle tachycardia human lung artery pressure male predictive value protein blood level second degree atrioventricular block sinus arrest ST segment elevation myocardial infarction supraventricular premature beat
Subjects: WG Cardiovascular System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 02 May 2020 04:22
Last Modified: 02 May 2020 04:22
URI: http://eprints.mums.ac.ir/id/eprint/16976

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