Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians

Ghayour-Mobarhan, M. and Taylor, A. and Lamb, D. J. and Ferns, G. A. A. (2007) Association between indices of body mass and antibody titres to heat-shock protein-60, -65 and -70 in healthy Caucasians. International Journal of Obesity, 31 (1). pp. 197-200.

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Abstract

We have previously shown that antibody titres to several heat-shock proteins (Hsps) are elevated in dyslipidaemic patients and subjects with established vascular disease. Obesity is known to be associated with raised serum inflammatory markers suggesting a state of heightened immune activation. Hence, we have investigated the association between indices of obesity and several Hsp antibody titres in healthy subjects. Subjects (n=170) were recruited from among employees at the University of Surrey and the Royal Surrey County Hospital, Guildford, UK. Of these subjects, 35 were obese with a body mass index (BMI)≥30 kg/m2 (19 male and 16 female subjects), 58 were overweight with 30>BMI≥25 kg/m2 (36 male and 22 female subjects) and 77 were of a normal weight with BMI<25 kg/m2 (31 male and 46 female subjects). Overall, obese subjects had significantly higher plasma anti-Hsp-60 (P<0.001), anti-Hsp-65 (P<0.05) and anti-Hsp-70 (P<0.05) compared with overweight and normal weight subjects. © 2007 Nature Publishing Group All rights reserved.

Item Type: Article
Additional Information: Cited By :14 Export Date: 16 February 2020 CODEN: IJOBD Correspondence Address: Ferns, G.A.A.; Center for Clinical Science and Measurement, School of Biological Sciences, University of Surrey, Guildford, Surrey GU2 5XH, United Kingdom; email: g.ferns@surrey.ac.uk
Uncontrolled Keywords: Antibody titres BMI Heat-shock proteins heat shock protein 60 heat shock protein 65 heat shock protein 70 adult analytic method antibody titer article body mass body weight Caucasian comparative study controlled study employee female human major clinical study male obesity priority journal United Kingdom Antibodies Blood Glucose Blood Pressure Body Mass Index Body Size C-Reactive Protein Chaperonin 60 Cholesterol HSP70 Heat-Shock Proteins Humans Middle Aged Triglycerides
Subjects: QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 05 May 2020 05:15
Last Modified: 05 May 2020 05:16
URI: http://eprints.mums.ac.ir/id/eprint/16989

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