Effect of tamsulosin versus prazosin on clinical and urodynamic parameters in women with voiding difficulty: A randomized clinical trial

Hajebrahimi, S. and Asrbadr, Y. A. and Azaripour, A. and Sadeghi-Bazargani, H. (2011) Effect of tamsulosin versus prazosin on clinical and urodynamic parameters in women with voiding difficulty: A randomized clinical trial. International Journal of General Medicine, 4. pp. 35-39.

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Abstract

Objective: To compare the effects of tamsulosin and prazosin on clinical and urodynamic parameters in women with voiding dysfunction. Methods: Forty women aged 20-65 years with a clinical diagnosis of voiding dysfunction were blindly randomized to two equal groups for treatment with tamsulosin 0.4 mg or 1-2 mg of prazosin daily. Symptom assessment with the American Urological Association Symptom Score (AUASS) and urodynamic evaluation was performed initially and after three months of treatment. Patient satisfaction was evaluated and severe adverse drug effects recorded. Statistical analysis was carried out using the Student's t-test and Mann-Whitney U test. Results: Although AUASS improved in both groups, the rate of improvement was larger in the tamsulosin group. Urodynamic parameters improved but did not normalize in both groups. Adverse side effects from medication in the prazosin group were more common than in the tamsulosin group. Most of the patients in the tamsulosin group (80) were satisfied with their treatment compared with those in the prazosin group (45). Conclusion: Tamsulosin and prazosin are both effective in palliating symptoms of women with voiding dysfunction and improving their urodynamic parameters. Tamsulosin may be the preferred drug to prescribe because of its more amenable side effect profile and greater patient satisfaction. © 2011 Daniotti et al.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 Correspondence Address: Hajebrahimi, S.; Urology Department, Imam Reza University Hospital, Golgasht Ave, Tabriz, Iran; email: hajebrahimis@gmail.com
Uncontrolled Keywords: Prazosin Tamsulosin Voiding dysfunction adult aged article bladder neck stenosis blurred vision clinical article controlled study disease severity dizziness drowsiness drug effect drug efficacy drug preference drug tolerability female headache human orthostatic hypotension outcome assessment palliative therapy patient assessment patient compliance patient satisfaction prescription randomized controlled trial risk reduction treatment duration urodynamics
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 24 Apr 2020 18:30
Last Modified: 24 Apr 2020 18:30
URI: http://eprints.mums.ac.ir/id/eprint/16996

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