Human papillomavirus infection in lung vs. oral squamous cell carcinomas: A polymerase chain reaction study

Halimi, M. and Morshedi Asl, S. and Saeid Hejazi, M. and Aghbali, A. and Esmaeil Hejazi, M. (2011) Human papillomavirus infection in lung vs. oral squamous cell carcinomas: A polymerase chain reaction study. Pakistan Journal of Biological Sciences, 14 (11). pp. 641-646.

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The role of Human Papillomavirus (HPV) has been suspected in pathogenesis of various malignancies; however, the available data are not conclusive. This study aimed to determine and compare the frequency of HPV infection in oral and lung Squamous Cell Carcinoma (SCC) by a sensitive method. Sixty specimens of oral and lung SCC (30 cases each one) were reevaluated in Tabriz Imam Reza Centre in a 24 month period. Following genomic DNA extract, the Polymerase Chain Reaction (PCR) amplification was performed in presence of specific MY11 and MY09 primers for HPV infection. Three cervical specimens and a combination of PCR solution lacking DNA plus healthy persons' DNA samples were employed as positive and negative controls, respectively. The oral group was significantly older than the lung group (68.90 vs. 56.67 y, p<0.001) with more males in the latter (83.3 vs. 60; p = 0.04). Percentages of HPV infection in the oral and lung groups were comparable (20 vs. 10, respectively; p = 0.47). Majority of patients with HPV infection were older than 60 years (88.9) or male (88.9). In the oral group, all these cases were well differentiated and the majority was of lower lip origin (83.3). In the lung group, 66.7 of these specimens were moderately differentiated and the origin was bronchus in all cases. In conclusion, the rate of HPV infection in lung and oral SCC samples is rather lower than the previous reports in the literature. This rate is apparently higher in the oral than the lung SCC specimens. ©2011 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Halimi, M.; Department of Pathology, Tabriz University of Medical Sciences, Imam Reza HospitalIran
Uncontrolled Keywords: Lung Oral cavity Papillomavirus infection Polymerase chain reaction Squamous cell carcinoma Human papillomavirus Papillomaviridae
Subjects: WC Communicable Diseases
WF Respiratory System
WU Dentistry. Oral surgery
QY Clinical Pathology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 29 Apr 2020 04:53
Last Modified: 29 Apr 2020 04:53

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