Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle

Hosseinzadeh, H. and Hosseini, A. and Nassiri-Asl, M. and Sadeghnia, H. R. (2007) Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle. BMC Complementary and Alternative Medicine, 7.

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Background: Salvia leriifolia have been shown to decrease ischemia-reperfusion (I/R) injury in brain tissues. In this study, the effects of S. leriifolia aqueous and ethanolic extracts were evaluated on an animal model of I/R injury in the rat hind limb. Methods: Ischemia was induced using free-flap surgery in skeletal muscle. The aqueous and ethanolic extracts of S. leriifolia (100, 200 and 400 mg/kg) root and normal saline (10 ml/kg) were administered intraperitoneally 1 h prior reperfusion. During preischemia, ischemia and reperfusion conditions the electromyographic (EMG) potentials in the muscles were recorded. The markers of oxidative stress including thiobarbituric acid reactive substances (TBARS), total sulfhydryl (SH) groups and antioxidant capacity of muscle (using FRAP assay) were measured. Results: In peripheral ischemia, the average peak-to-peak amplitude during ischemic-reperfusion was found to be significantly larger in extracts groups in comparison with control group. Following extracts administration, the total SH contents and antioxidant capacity were elevated in muscle flap. The MDA level was also declined significantly in test groups. Conclusion: It is concluded that S. leriifolia root extracts have some protective effects on different markers of oxidative damage in muscle tissue injury caused by lower limb ischemia-reperfusion. © 2007 Hosseinzadeh et al; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Cited By :18 Export Date: 16 February 2020 CODEN: BCAMC Correspondence Address: Hosseinzadeh, H.; Department of Pharmacology and Toxicology, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; email: hosseinzadehh@mums.ac.ir
Uncontrolled Keywords: alcohol plant medicinal product Salvia leriifolia extract sodium chloride thiobarbituric acid reactive substance thiol derivative unclassified drug antioxidant plant extract animal experiment animal model antioxidant activity article controlled study electromyography extraction limb ischemia male muscle ischemia nonhuman oxidative stress plant root rat reperfusion injury Salvia Salvia leriifolia skeletal muscle statistical significance Wistar rat animal comparative study disease model drug effect intraperitoneal drug administration metabolism methodology phytotherapy Animals Antioxidants Disease Models, Animal Injections, Intraperitoneal Muscle, Skeletal Plant Extracts Plant Roots Rats Rats, Wistar Sulfhydryl Compounds Thiobarbituric Acid Reactive Substances
Subjects: WG Cardiovascular System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 23 Apr 2020 18:38
Last Modified: 23 Apr 2020 18:38
URI: http://eprints.mums.ac.ir/id/eprint/17013

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