Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice

Hosseinzadeh, H. and Karimi, G. R. and Ameri, M. (2002) Effects of Anethum graveolens L. seed extracts on experimental gastric irritation models in mice. BMC Pharmacology, 2.

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Abstract

Background: As a folk remedy, Anethum graveolens seed (dill) is used for some gastrointestinal ailments. We aimed to evaluate aqueous and ethanolic extracts of anti-ulcer and acute toxicity effects of the Anethum graveolens in mice. Results: Gastric mucosal lesions were induced by oral administration of HCl (1 N) and absolute ethanol in mice. The acidity and total acid content of gastric juice were measured in pylorus-ligated mice. LD50 values of the aqueous and ethanolic extracts were 3.04 g/kg, i.p., (1.5, 6.16) and 6.98 g/kg, i.p., (5.69, 8.56), respectively. The efficacy of high dose of extracts (p.o.) was similar to sucralfate. The acidity and total acid content were reduced by the orally or intraperitoneally administration of the extracts. Conclusions: The results suggest that A. graveolens seed extracts have significant mucosal protective and antisecretory effects of the gastric mucosa in mice. © 2002 Hosseinzadeh et all; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Cited By :63 Export Date: 16 February 2020 CODEN: BPMHB Correspondence Address: Hosseinzadeh, H.; Pharmaceutical Research Center, Dept. of Pharmacodynamy/Toxicology, Mashhad University of Medical Sci., P.O. Box 91775-1365, Mashhad, Iran; email: hosseinzadehh@yahoo.com
Uncontrolled Keywords: alcohol anethum graveolens extract cimetidine hydrochloric acid ketamine plant extract sodium chloride sucralfate unclassified drug xylazine antiulcer agent acute toxicity animal experiment animal model aqueous solution article cell protection controlled study dose response drug activity drug efficacy drug mechanism drug megadose drug potency LD 50 male mouse nonhuman pylorus ligation stomach acid stomach juice stomach mucosa lesion stomach pH stomach secretion stomach ulcer animal Bagg albino mouse chemically induced disorder chemistry dill disease model plant seed secretion Anethum graveolens Animals Anti-Ulcer Agents Disease Models, Animal Gastric Acid Mice Mice, Inbred BALB C Plant Extracts Seeds
Subjects: WI Digestive System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 25 Apr 2020 07:52
Last Modified: 25 Apr 2020 07:52
URI: http://eprints.mums.ac.ir/id/eprint/17014

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