Antinociceptive, Anti-inflammatory Effects and Acute Toxicity of Aqueous and Ethanolic Extracts of Myrtus communis L. Aerial Parts in Mice

Hosseinzadeh, H. and Khoshdel, M. and Ghorbani, M. (2011) Antinociceptive, Anti-inflammatory Effects and Acute Toxicity of Aqueous and Ethanolic Extracts of Myrtus communis L. Aerial Parts in Mice. JAMS Journal of Acupuncture and Meridian Studies, 4 (4). pp. 242-247.

[img] Text
Antinociceptive, Anti-inflammatory Effects and Acute Toxicity of Aqueous and Ethanolic Extracts of Myrtus communis L. Aerial Parts in Mice.pdf

Download (638kB)

Abstract

Myrtus communis L. aerial parts have been used in traditional medicine for the treatment of inflammatory disease. In this study 350 mice were divided into three main groups: negative (saline), positive (morphine or diclofenac) controls, and test groups. The acute toxicity was assessed for 2 days. Antinociceptive activity was performed using hot plate and writhing tests. The anti-inflammatory effect was investigated using xylene-induced ear edema and a cotton pellet test. According to phytochemical screening, the extracts contained tannins, alkaloids, and flavonoids. The LD50 values of the aqueous and ethanolic extracts were 0.473 and 0.79. g/kg, respectively. In hot plate test, the aqueous and ethanolic extracts showed significant antinociceptive activity that was inhibited by naloxone. The extracts exhibited antinociceptive activity against acetic acid-induced writhing and also showed significant activity against acute inflammation which was dose dependent for aqueous extract. The ethanolic (0.05. g/kg) and aqueous extracts (0.005, 0.015, and 0.03. g/kg) demonstrated anti-inflammatory effects against chronic inflammation. The aqueous and ethanolic extracts of the aerial parts of M communis L. showed antinociceptive effects and these may be mediated by opioid receptors. © 2011.

Item Type: Article
Additional Information: Cited By :43 Export Date: 16 February 2020 Correspondence Address: Hosseinzadeh, H.; Pharmaceutical Research Center, Pharmacodynamy and Toxicology Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; email: hosseinzadehh@mums.ac.ir
Uncontrolled Keywords: Acute toxicity Anti-inflammatory Antinociceptive Mice Myrtus communis L. acetic acid alcohol alkaloid diclofenac flavonoid morphine Myrtus communis extract naloxone plant medicinal product tannin xylene animal experiment animal model animal tissue antiinflammatory activity antinociception article chronic inflammation controlled study drug screening ear disease edema hot plate test inflammation LD 50 male mouse myrtle nonhuman phytochemistry priority journal writhing test Analgesics Animals Anti-Inflammatory Agents Anti-Inflammatory Agents, Non-Steroidal Humans Myrtus Phytotherapy Plant Components, Aerial Plant Extracts
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 19 Apr 2020 05:29
Last Modified: 19 Apr 2020 05:29
URI: http://eprints.mums.ac.ir/id/eprint/17015

Actions (login required)

View Item View Item