Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice

Hosseinzadeh, H. and Nassiri Asl, M. (2003) Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice. BMC Pharmacology, 3.

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Abstract

Background: Carbenoxolone, as an antiulcer medicine, has some pharmacological properties such as: the inhibition of gap junctional (GJ) intercellular communication. In vitro studies have shown, carbenoxolone to abolish the generation of full or partial ectopic spike generation, by 4-aminopyridine, as well as spontaneous epileptiform activity in CA3 or CA1 regions of the rat hippocampal slices via closing GJ channels. Thus, we considered the possible anticonvulsant effects of carbenoxolone in animal seizure models. Results: ED50 values of diazepam and carbenoxolone in the pentylenetetrazole model were 1.13 mg/kg and 283.3 mg/kg, respectively. In this model, carbenoxolone in doses of 200 and 300 mg/kg prolonged the onset time of seizure and decreased the duration of seizures. In the maximal electroshock model, carbenoxolone in a dose of 400 mg/kg decreased the duration of seizure producing protection against seizure but failing to protect against mortality in comparison with diazepam. In the potentiation of pentobarbitone sleep test, carbenoxolone significantly increased sleeping time and decreased latency in doses of 100, 200 and 300 mg/kg in mice dose dependently. In the traction test, carbenoxolone (400 mg/kg) showed muscle relaxant activity and in the accelerated rotarod test, carbenoxolone in doses of 200 and 300 mg/kg showed a decline in motor coordination. Conclusion: It can be concluded that carbenoxolone possesses anticonvulsant, muscle relaxant and hypnotic effects, which could contribute to the control of petit mal and grand mal seizures. © 2003 Hosseinzadeh and Nassiri Asl; licensee BioMed Central Ltd.

Item Type: Article
Additional Information: Cited By :69 Export Date: 16 February 2020 CODEN: BPMHB Correspondence Address: Hosseinzadeh, H.; Pharmaceutical Research Center, Faculty of Pharmacy, Mashhad University of Medical Sci., P.O. Box 1365-91775, Mashhad, Iran; email: hosseinzadehh@yahoo.com
Uncontrolled Keywords: 4 aminopyridine anticonvulsive agent carbenoxolone diazepam muscle relaxant agent pentetrazole pentobarbital sedative agent animal experiment animal model anticonvulsant activity article brain region brain slice controlled study disease model dose response drug dose drug efficacy electric shock epileptic discharge grand mal seizure hippocampus male mortality motor coordination mouse muscle relaxation nonhuman petit mal seizure sleep time synaptic transmission
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 19 Apr 2020 05:11
Last Modified: 19 Apr 2020 05:11
URI: http://eprints.mums.ac.ir/id/eprint/17016

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