Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice

Hosseinzadeh, H. and Younesi, H. M. (2002) Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacology, 2.

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Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice.pdf

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Abstract

Background: Crocus sativus L. (saffron) is used in folk medicine, for example as an antiedematogenic agent. We aimed to evaluate the antinociceptive and anti-inflammatory activity of saffron extracts in mice. Results: We used aqueous and ethanolic maceration extracts of Crocus sativus L. stigma and petals. Antinociceptive activity was examined using the hot plate and writhing tests. The effect of extracts against acute inflammation was studied using xylene induced ear edema in mice. The activity of the extracts against chronic inflammation was assessed by formalin-induced edema in the rat paw. In the hot plate tests, intraperitoneal injection of both extracts showed no significant antinociceptive activity in mice. The extracts exhibited antinociceptive activity against acetic acid induced writhing. Naloxone partially blocked only the antinociceptive activity of the stigma aqueous extract. Only the stigma extracts showed weak to moderate effect against acute inflammation. In chronic inflammation, both aqueous and ethanolic stigma extracts, as well as ethanolic petal extract, exerted anti-inflammatory effects. Conclusions: We conclude that aqueous and ethanolic extracts of saffron stigma and petal have an antinociceptive effect, as well as acute and/or chronic anti-inflammatory activity. © 2002 Hosseinzadeh and Younesi; licensee BioMed Centra Ltd.

Item Type: Article
Additional Information: Cited By :424 Export Date: 16 February 2020 CODEN: BPMHB Correspondence Address: Hosseinzadeh, H.; Dept. of Pharmacodynamy/Toxicology, School of Pharmacy, Mashhad University of Medical Sci., PO Box 91775-1365, Mashhad, Iran; email: hosseinzadehh@yahoo.com
Uncontrolled Keywords: acetic acid alkaloid anthocyanin antiinflammatory agent antinociceptive agent crocus sativus extract dexamethasone diclofenac flavonoid formaldehyde morphine naloxone plant extract saponin tannin derivative unclassified drug xylene animal experiment animal model antiinflammatory activity antinociception aqueous solution article chronic inflammation controlled study Crocus crocus sativus drug effect drug screening ear disease female hot plate test inflammation male mouse nonhuman paw edema petal pistil stigma traditional medicine writhing test
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 19 Apr 2020 05:15
Last Modified: 19 Apr 2020 05:15
URI: http://eprints.mums.ac.ir/id/eprint/17017

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