Antiviral activities of aerial subsets of Artemisia species against Herpes Simplex virus type 1 (HSV1) in vitro

Karamoddini, M. K. and Emami, S. A. and Ghannad, M. S. and Sani, E. A. and Sahebkar, A. (2011) Antiviral activities of aerial subsets of Artemisia species against Herpes Simplex virus type 1 (HSV1) in vitro. Asian Biomedicine, 5 (1). pp. 63-68.

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Abstract

Background: Drug resistance to current anti-herpetic drugs has been increasingly reported. Therefore, there is a need for finding new antiviral agents, in particular from natural sources. Objective: In the present study, antiviral activity of subset extracts obtained from aerial parts of Artemisia including A. incana, A. chamaemelifolia, A. campesteris, A. fragrans, A. annua, A. vulgaris, and A. persica were investigated against Herpes Simplex type I (HSV1). Methods: Different concentrations of extracts (400, 200, 100, 50, 25, 12.5, 6.25, and 3.125 μg/mL) were obtained from subset of each plant separately, and used against KOS strain of HSV1 in HeLa cells. After 24 hours incubation, tetrazolium dye (MTT), was added. The dye absorption by viable cells was measured and compared to the positive control (extract-untreated cells) and acyclovir (as anti-viral agent). Results: The extracts obtained from A. annua had the highest antiviral activity while those of A. chamaemelifolia showed the lowest activity. Conclusion: Subset extracts of A. annua may be an appropriate candidate for further development of anti HSV1 infection.

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 Correspondence Address: Ghannad, M.S.; Department of Microbiology, Medical School, Hamadan University of Medical Sciences, Hamadan 65178-3-8736, Iran; email: sabouri39@yahoo.com
Uncontrolled Keywords: Antivirals Artemisia Asteraceae Herpes simplex aciclovir antivirus agent Artemisia annua extract Artemisia campesteris extract Artemisia chamaemelifolia extract Artemisia fragrans extract Artemisia incana extract Artemisia persica extract Artemisia vulgaris extract methanol plant extract unclassified drug antiviral activity Artemisia annua Artemisia campesteris Artemisia chamaemelifolia Artemisia fragrans Artemisia incana Artemisia persica Artemisia vulgaris article cell viability controlled study HeLa cell Herpes simplex virus 1 in vitro study nonhuman solvent extraction
Subjects: QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 28 Apr 2020 04:56
Last Modified: 28 Apr 2020 04:56
URI: http://eprints.mums.ac.ir/id/eprint/17027

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