Cisplatin nephrotoxicity and protection by milk thistle extract in rats

Karimi, G. and Ramezani, M. and Tahoonian, Z. (2005) Cisplatin nephrotoxicity and protection by milk thistle extract in rats. Evidence-based Complementary and Alternative Medicine, 2 (3). pp. 383-386.

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The protective effect of methanolic extract of milk thistle seeds and silymarin against cisplatin-induced renal toxicity in male rats after a single intraperitoneal injection of 3 mg kg-1 cisplatin were studied. Over 5 days, cisplatin-treated rats showed tubular necrosis and elevation in blood urea nitrogen (BUN) and serum creatinine (Scr). Pretreatment of animals with silymarin (50 mg kg-1) or extract (0.6 g kg-1) 2 h before cisplatin prevented the tubular damage. Rats treated with silymarin or extract 2 h after cisplatin had BUN and Scr significantly lower than those receiving cisplatin, but mild to moderate necrosis was observed. These results suggested that milk thistle may protect against cisplatin-induced renal toxicity and might serve as a novel combination agent with cisplatin to limit renal injury. © The Author (2005). Published by Oxford University Press. All rights reserved.

Item Type: Article
Additional Information: Cited By :73 Export Date: 16 February 2020 Correspondence Address: Karimi, G.; Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Khorasan 91775-1365, Iran; email:
Uncontrolled Keywords: Cisplatin Milk thistle Renal toxicity Silymarin creatinine methanol nitrogen Silybum marianum extract urea acute kidney failure animal experiment animal tissue article controlled study creatinine blood level drug effect kidney injury kidney tubule necrosis male nephrotoxicity nonhuman premedication priority journal rat renal protection Silybum marianum species comparison urea nitrogen blood level
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 20 Apr 2020 09:33
Last Modified: 20 Apr 2020 09:33

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