The Prevalence of Occult Celiac Disease among patients with functional dyspepsia: A study from the Western Region of Iran

Keshavarz, A. A. and Bashiri, H. and Ahmadi, A. and Bazargan-Hejazi, S. (2010) The Prevalence of Occult Celiac Disease among patients with functional dyspepsia: A study from the Western Region of Iran. Gastroenterology Research and Practice.

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Objective. The prevalence of Celiac Disease (CD) is high in Iran, and evaluation of CD is not part of the routine screening procedure for dyspeptic patients; therefore, cases of occult CD may be missed. This study aimed to investigate the prevalence of occult CD among dyspeptic patients who presented at a gastroenterology clinic in the Western region of Iran. Methods. In this descriptive, cross-sectional prospective study, patients who had a history of at least 12 weeks of upper abdominal discomfort were eligible to participate in the study during a 14-month recruitment period. Patients with a clinical or paraclinical data in favor of organic causes were excluded from the study. Enrolled patients were screened for IgA antiendomysium antibody (EMA) and IgA antitissue transglutaminase antibody (tTG). Those who screened positive for EMA/tTG received a confirmatory diagnostic biopsy for Marsh classification of CD. Results. From 225 potential participants with dyspepsia, 55 patients were excluded due to having explainable organic causes. The study sample included 170 patients with functional dyspepsia. Mean age of participants was 31 years and 55.8 were female. Twelve patients (7) had positive tests (EMA/tTG), of which 10 were female (83.4). According to Rome II criteria, all twelve patients with positive tests had dysmotility type dyspepsia. Based on Marsh classification, six patients were consistent with Marsh I, four with Marsh II, and two with the Marsh III classification. Conclusions. In this study, the prevalence of CD in dyspeptic patients was high. As a result, this study suggests that screening by serology tests (EMA/tTG) is justifiable for the detection of CD among functional dyspeptic patients in the tertiary centers in our country. Copyright © 2010 Ali Asghar Keshavarz et al.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Keshavarz, A. A.; Department of Gastroenterology and Hepatology, Imam Reza Hospital, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran; email:
Uncontrolled Keywords: immunoglobulin A protein glutamine gamma glutamyltransferase antibody abdominal discomfort adult article celiac disease cross-sectional study dyspepsia female gastroenterology human Iran major clinical study male prevalence prospective study
Subjects: WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 02 May 2020 05:32
Last Modified: 02 May 2020 05:32

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