Ethnic and geographic differentiation of Helicobacter pylori within Iran

Latifi-Navid, S. and Ghorashi, S. A. and Siavoshi, F. and Linz, B. and Massarrat, S. and Khegay, T. and Salmanian, A. H. and Shayesteh, A. A. and Masoodi, M. and Ghanadi, K. and Ganji, A. and Suerbaum, S. and Achtman, M. and Malekzadeh, R. and Falush, D. (2010) Ethnic and geographic differentiation of Helicobacter pylori within Iran. PLoS ONE, 5 (3).

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The bacterium Helicobacter pylori colonizes the human stomach, with individual infections persisting for decades. The spread of the bacterium has been shown to reflect both ancient and recent human migrations. We have sequenced housekeeping genes from H. pylori isolated from 147 Iranians with well-characterized geographical and ethnic origins sampled throughout Iran and compared them with sequences from strains from other locations. H. pylori from Iran are similar to others isolated from Western Eurasia and can be placed in the previously described HpEurope population. Despite the location of Iran at the crossroads of Eurasia, we found no evidence that the region been a major source of ancestry for strains across the continent. On a smaller scale, we found genetic affinities between the H. pylori isolated from particular Iranian populations and strains from Turks, Uzbeks, Palestinians and Israelis, reflecting documented historical contacts over the past two thousand years. © 2010 Latifi-Navid et al.

Item Type: Article
Additional Information: Cited By :39 Export Date: 16 February 2020 Correspondence Address: Falush, D.; Department of Microbiology, Environmental Research Institute, University College Cork, Cork, Ireland; email:
Uncontrolled Keywords: bacterial antigen bacterial DNA article biological model DNA sequence ethnic group ethnology gastrointestinal tract genetics geography Helicobacter infection Helicobacter pylori human Iran microbiology phylogeny species difference Antigens, Bacterial DNA, Bacterial Ethnic Groups Helicobacter Infections Humans Models, Genetic Sequence Analysis, DNA Species Specificity
Subjects: QU Biochemistry
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 26 Apr 2020 17:15
Last Modified: 26 Apr 2020 17:15

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