Systemic meglumine antimoniate in acute cutaneous leishmaniasis: Children versus adults

Layegh, P. and Rahsepar, S. and Rahsepar, A. A. (2011) Systemic meglumine antimoniate in acute cutaneous leishmaniasis: Children versus adults. American Journal of Tropical Medicine and Hygiene, 84 (4). pp. 539-542.

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Some studies showed that children have a lower response to systemic use of pentavalent antimoniate than adults. We aimed to evaluate the response rate to Glucantime therapy in children and compare it with adults. One hundred and twelve patients with acute cutaneous leishmaniais (ACL) were divided into two equal groups of adults (> 15 yrs) and children (? 15 yrs). They received meglumine antimoniate; 20 mg/kg/day for 20 days, their improvement rate was evaluated 20 and 45 days after treatment. Perprotocol analysis showed a significantly lower response in the children group 20 and 45 days after initiation of the treatment ( P = 0.0001, 95 confidence interval CI = 0.190 0.079-0.456/ P = 0.0051, 95% CI = 0.317 0.140-0.717, respectively). Moreover, after intention-to-treat analysis, the same results were seen in the younger group 20 and 45 days after treatment ( P = 0.0003, 95% CI = 0.228 0.098-0.528/ P = 0.0132, 95% CI = 0.382 0.177-0.825, respectively). According to our results, systemic Glucantime has lower efficacy in treating ACL in children than adults. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 CODEN: AJTHA Correspondence Address: Layegh, P.; Research Center for Skin Diseases and Cutaneous Leishmaniasis, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; email:
Uncontrolled Keywords: meglumine antimonate antiprotozoal agent meglumine meglumine antimoniate organometallic compound acute disease adolescent adult adult disease article child childhood disease clinical trial comparative study drug efficacy drug treatment failure female follow up groups by age human injection site erythema injection site pruritus intention to treat analysis Leishmania tropica major clinical study male nonhuman outcome assessment preschool child school child skin leishmaniasis smear treatment duration treatment response age patient compliance Age Factors Antiprotozoal Agents Child, Preschool Humans Leishmaniasis, Cutaneous Medication Adherence Organometallic Compounds Young Adult
Subjects: WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 03 May 2020 09:10
Last Modified: 03 May 2020 09:10

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