Epidermolytic hyperkeratosis in inflammatory linear verrucous epidermal nevus

Meibodi, N. T. and Nahidi, Y. and Javidi, Z. (2011) Epidermolytic hyperkeratosis in inflammatory linear verrucous epidermal nevus. Indian Journal of Dermatology, 56 (3). pp. 309-312.

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Epidermolytic hyperkeratosis presents with perinuclear vacuolization of the keratinocytes in spinous and granular layers, keratinocytes with ill-defined limits, which leads to a reticulate appearance of the epidermis, an increased number of variously shaped and sized basophilic keratohyalin granules and the same sized eosinophilic trichohyalin granules, at any level of epidermis, mainly in the stratum granulosum, and compact hyperkeratosis. This minor reactive pathologic reaction pattern of skin is found in large variety of diseases. This paper is the first case report of such pattern in inflammatory linear verrucous epidermal nevus. Our case is of a 23-year-old man with pruritic verrucous lesions of trunk and extremities initiated since 13 years ago. Physical examination revealed white linear hyperkeratotic lesions, some of them on erythematous background and also classic epidermal nevus. No skeletal, ophthalmic, and nervous system involvement was detected. Microscopic study of pruritic verrucous lesions showed psoriasiform acanthosis, mild papillomatous, hyperkeratosis, and epidermolytic hyperkeratotic changes in hair follicles and acrosyrinx accompanied with moderate perivascular inflammation.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 Correspondence Address: Nahidi, Y.; Departments of Pathology and Dermatology, Mashhad University of Medical Sciences, Imam-Reza Educational Hospital, Mashhad, Iran; email: nahidiy@mums.ac.ir
Uncontrolled Keywords: epidermal nevus Epidermolytic hyperkeratosis inflammatory linear verrucous epidermal nevus acanthosis adult article Becker nevus case report disease duration erythema hair follicle human inflammation male physical examination pruritus skin defect syndrome ILVEN
Subjects: WR Dermatology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 25 Apr 2020 10:06
Last Modified: 25 Apr 2020 18:40
URI: http://eprints.mums.ac.ir/id/eprint/17052

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