Typhoid myopathy or typhoid hepatitis: A matter of debate

Mirsadraee, M. and Shirdel, A. and Roknee, F. (2007) Typhoid myopathy or typhoid hepatitis: A matter of debate. Indian Journal of Medical Microbiology, 25 (4). pp. 351-353.

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Abstract

Purpose: The aim of the present study was to evaluate the major source of increased serum enzyme level in typhoid fever and to determine the most relevant clinical entity, hepatitis or myopathy, during typhoid fever. Methods: A total of 118 subjects proved to have typhoid fever were evaluated for serum enzymes such as transaminases, alkaline phosphatase, lactate dehydrogenase (LDH) and creatinine kinase (CK); and their relation with each other, clinical symptoms and serum bilirubin were evaluated by regression methods. Results: Hepatomegaly was revealed in 14 of the cases and was correlated with elevated serum biliribin (5.05 ± 13.03 mg/dL in hepatomegalic subjects). Alanine aminotransferase (ALT) and CK were elevated in 22 and 60 of the cases, respectively. Correlation coefficient of CK with aspartate aminotransferase (AST) and LDH was R2 = 0.68 and 0.75, respectively, which were higher than that of ALT with that two enzymes. Conclusions: In conclusion, elevation of serum enzymes in typhoid is mostly of muscular origin.

Item Type: Article
Additional Information: Cited By :12 Export Date: 16 February 2020 CODEN: IJMME Correspondence Address: Mirsadraee, M.; Department of Internal Medicine, Medical School of Islamic Azad University of Mashhad, Mashhad, Iran; email: majidmirsadraee@yahoo.com
Uncontrolled Keywords: Creatinine kinase Hepatitis Myopathy Transaminase Typhoid fever alanine aminotransferase alkaline phosphatase aspartate aminotransferase bilirubin creatine kinase enzyme lactate dehydrogenase adolescent adult alanine aminotransferase blood level analytic method article aspartate aminotransferase blood level bilirubin blood level child controlled study correlation coefficient enzyme blood level female hepatomegaly human lactate dehydrogenase blood level major clinical study male regression analysis
Subjects: WC Communicable Diseases
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 04 May 2020 03:55
Last Modified: 04 May 2020 03:55
URI: http://eprints.mums.ac.ir/id/eprint/17054

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