High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran

Moghbeli, M. and Moaven, O. and Dadkhah, E. and Farzadnia, M. and Roshan, N. M. and Asadzadeh-Aghdaee, H. and Bahar, M. M. and Raeisossadati, R. and Forghanifard, M. M. and Bakhtiari, S. R. E. A. and Baradaran, A. and Abbaszadegan, M. R. (2011) High frequency of microsatellite instability in sporadic colorectal cancer patients in Iran. Genetics and Molecular Research, 10 (4). pp. 3520-3529.

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Abstract

Microsatellite instability in sporadic colorectal cancer patients was assessed, and the clinicopathological associations were evaluated in northeastern Iran, which is a high-risk region for gastrointestinal malignancies. Microsatellite instability (MSI) status of tumoral tissue, compared to normal tissue, was assessed witha standard panel of MSI markers on paraffin-embedded surgically resected tissues from 67 consecutive sporadic colorectal cancer patients. Eleven of the patients were under 40 years old. Female patients were significantly younger than male patients (mean age 54.2 vs 62.1 years. P = 0.020). MSI analysis revealed 18 cases of MSI-H (26.9). 11 MSI-L (16.4) and 38 MSS (microsatellite stable tumors; 56.7). While a greater proportion of patients consisted of males, 56.7 vs 43.3 females, MSI-H was more frequent in females (34.5 vs 21.5). MSI was associated with proximal location of tumor (P = 0.003) and lower stages of tumor (P = 0.002). while MSS tumors were associated with node metastasis. MSI has a higher frequency in sporadic colorectal cancer patients, suggesting that molecular epidemiology of the genetic alterations involved in colorectal cancer carcinogenesis has a different pattern in the Iranian population, which deserves further epidemiological attention. The high frequency of MSI-H in this population suggests that we should look at microsatellite instability prior to chemotherapy to determine the most appropriate chemotherapeutic strategy in our population. © FUNPEC-RP www.funpecrp.com.br.

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 Correspondence Address: Abbaszadegan, M.R.; Division of Human Genetics, Immunology Research Center, Avicenna Research Institute, Mashhad University of Medical SciencesIran; email: abbaszadeganmr@mums.ac.ir
Uncontrolled Keywords: Iran Microsatellite instability Mismatch repair Sporadic colorectal cancer antineoplastic agent adult aged Article cancer chemotherapy cancer genetics cancer localization cancer patient cancer staging clinical feature colon carcinogenesis colorectal cancer colorectal surgery controlled study DNA modification female genetic analysis genetic association high risk patient histopathology human human tissue Iranian people lymph node metastasis major clinical study male microsatellite marker molecular epidemiology population genetics population research sex difference colorectal tumor genetic marker genetics heterozygosity loss middle aged pathology Aged, 80 and over Colorectal Neoplasms Genetic Markers Humans Loss of Heterozygosity
Subjects: WI Digestive System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 29 Apr 2020 04:30
Last Modified: 29 Apr 2020 04:30
URI: http://eprints.mums.ac.ir/id/eprint/17060

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