Expression of membranous epidermal growth factor receptor in colorectal adenocarcinoma and it's correlation with clinicopathological features

Mohammadi, G. and Jamialahmadi, K. and Lary, S. and Ghaffarzadegan, K. (2011) Expression of membranous epidermal growth factor receptor in colorectal adenocarcinoma and it's correlation with clinicopathological features. Pakistan Journal of Biological Sciences, 14 (5). pp. 357-362.

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Abstract

The aim of this study was to investigate the expression of membranous epidermal growth factor receptor in colorectal adenocarcinoma and it's correlation with clinicopathological features. Fifty formalin-fixed, paraffin embedded archival specimens of colorectal cancer were included randomly as cases. Immunohistochemical staining was performed to assess EGFR expression. The results were correlated with the clinicopathological features of colorectal tumor tissues. More than 1 of membranous EGFR expression was found in 24 (48) of cancer specimens. The immunoreactions intensity was classified as weak, moderate and strong representing 2, 22 and 24, respectively. According to multivariate analysis, EGFR expression was not significantly associated with age, sex, tumor site, stage, grade and type of tumor in cases. These results suggest that the assessment of EGFR expression in colorectal cancer by conventional immunohistochemistry has not proven its predictive value and can not be useful to predict about outcome of patients.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Jamialahmadi, K.; Department of Biology, Payam Noor University of Mashhad, Mashhad, Iran
Uncontrolled Keywords: Clinicopathologic feautre Colorectal cancer Epidermal growth factor receptor Immunohistochemistry Proliferation TMT stage adenocarcinoma adult aged article colorectal tumor female human Iran male metabolism middle aged pathology predictive value prognosis Aged, 80 and over Colorectal Neoplasms Humans Predictive Value of Tests Receptor, Epidermal Growth Factor
Subjects: QY Clinical Pathology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 26 Apr 2020 18:30
Last Modified: 26 Apr 2020 18:30
URI: http://eprints.mums.ac.ir/id/eprint/17061

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