The expression of heat shock proteins 27 and 105 in squamous cell carcinoma of the tongue and relationship with clinicopathological index

Mohtasham, N. and Babakoohi, S. and Montaser-Kouhsari, L. and Memar, B. and Salehinejad, J. and Rahpeyma, A. and Khageh-Ahmady, S. and Marouzi, P. and Firooz, A. and Pazoki-Toroudi, H. and Anvari, K. (2011) The expression of heat shock proteins 27 and 105 in squamous cell carcinoma of the tongue and relationship with clinicopathological index. Medicina Oral, Patologia Oral y Cirugia Bucal, 16 (6). pp. 730-735.

[img] Text
The expression of heat shock proteins 27 and 105 in squamous cell carcinoma of the tongue and relationship with clinicopathological index.pdf

Download (723kB)
[img] Text
medoralv16_i6_p730.pdf

Download (723kB)

Abstract

Introduction: In oral cavity, the tongue is the most common site prone to development of squamous cell carcinoma (SCC). Considering malignant transformation as a cellular stress, the expression of heat shock proteins (HSPs) may be affected in this process. In this study we assessed the expression of HSP105 and HSP27 as two of the most interested stress proteins and investigated their relationship with grade and stage of the tongue SCC. Material and Methods: Fifty-six specimens including 31 early and 25 advanced tongue SCC were gathered. All specimens were graded histologically from I to III. Sixteen sections of normal oral mucosa were used as control group. The cellularity and intensity of HSP105 and HSP27 expression were studied immunohistochemically in both case and control groups. Results were expressed by histochemical score (HSCORE). Results: Significant differences were observed between expression of HSPs and stage of the disease. From early to advanced stage, the expression of HSP105 and HSP27 increased and decreased, respectively. There was no relationship between histological grade of lesion and HSCORE of HSP105 expression (P=0.5), although, HSP27 expression had reverse relationship with the SCC histological grade. Conclusion: HSP27 and HSP105 may be indicated for prognostic purposes in evaluation of tongue SCC. HSP 27 may be used for more accurate microscopic grading of tongue SCC. Increased expression of HSP105 in advanced stage may lead to using this protein for immunotherapy of tongue SCC. © Medicina Oral S. L.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 Correspondence Address: Babakoohi, S.; Omid Hospital-Alandash Square, Koohsangi Avenue, Mashhad, Iran; email: shahabmdt@gmail.com
Uncontrolled Keywords: Heat shock protein 105 Heat shock protein 27 Tongue squamous cell carcinoma heat shock protein unclassified drug adult advanced cancer article cancer grading cancer staging clinical article controlled study histopathology human human cell human tissue immunohistochemistry protein expression squamous cell carcinoma tongue carcinoma Carcinoma, Squamous Cell HSP110 Heat-Shock Proteins HSP27 Heat-Shock Proteins Humans Middle Aged Retrospective Studies Tongue Neoplasms
Subjects: WU Dentistry. Oral surgery
QY Clinical Pathology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 04 May 2020 05:49
Last Modified: 04 May 2020 05:49
URI: http://eprints.mums.ac.ir/id/eprint/17063

Actions (login required)

View Item View Item