Feselol enhances the cytotoxicity and DNA damage induced by cisplatin in 5637 cells

Mollazadeh, S. and Matin, M. M. and Bahrami, A. R. and Iranshahi, M. and Behnam-Rassouli, M. and Rassouli, F. B. and Neshati, V. (2011) Feselol enhances the cytotoxicity and DNA damage induced by cisplatin in 5637 cells. Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 66 (11-12). pp. 555-561.

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Abstract

Transitional cell carcinoma (TCC), which is the most common type of bladder cancer, shows resistance to chemotherapeutic agents due to the overexpression of drug efflux pumps. In this study, the effects of feselol, a sesquiterpene coumarin extracted from Ferula badrakema, on cisplatin cytotoxicity were investigated in 5637 cells, a TCC subline. Cell viability and DNA lesion were evaluated by thiazolyl blue tetrazolium bromide and comet assays, respectively. Feselol had no significant cytotoxic effect in 5637 cells but at 32 μg/mL it increased the cytotoxicity of 1 μg/mL cisplatin by 37 after 24 h. Furthermore, the comet assay revealed that DNA damage induced by cisplatin in 5637 cells is enhanced by 31 when used in combination with feselol. Therefore, feselol might be considered as an effective reversal agent for future in vivo and clinical studies. © 2011 Verlag der Zeitschrift für Naturforschung, Tübingen.

Item Type: Article
Additional Information: Cited By :3 Export Date: 16 February 2020 CODEN: ZNCBD Correspondence Address: Matin, M. M.; Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran; email: Matin@um.ac.ir
Uncontrolled Keywords: 5637 Cells Cisplatin Feselol Ferula
Subjects: W General medicine- Health professions
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 28 Apr 2020 05:33
Last Modified: 28 Apr 2020 05:33
URI: http://eprints.mums.ac.ir/id/eprint/17065

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