Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism

Morteza Taghavi, S. and Rokni, H. and Fatemi, S. (2011) Metformin decreases thyrotropin in overweight women with polycystic ovarian syndrome and hypothyroidism. Diabetes and Vascular Disease Research, 8 (1). pp. 47-48.

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Abstract

Objective: To assess the effect of metformin administration on thyroid function in overweight women with polycystic ovarian syndrome (PCOS). Methods: Twenty-seven overweight women with PCOS and hypothyroidism were selected. Fifteen patients (group I) were treated with metformin 1500 mg/day for 6 months and 12 patients (group II) with placebo. Serum thyrotropin (TSH), free T3 and free T4 were measured at baseline and 6 months after the beginning of the study. Results: A significant decrease (p<0.001) in TSH levels was observed in group I but not in group II subjects after 6 months of metformin treatment. No significant change in free T3 and free T4 was observed throughout the study in any group. Conclusion: In obese PCOS patients with primary hypothyroidism, metformin results in a significant fall and sometimes normalisation of TSH, without causing any reciprocal changes in other thyroid function parameters. © The Author(s) 2011.

Item Type: Article
Additional Information: Cited By :35 Export Date: 16 February 2020 Correspondence Address: Morteza Taghavi, S.; Endocrine Research Center, Mashhad Medical University, Ghaem Hospital, Ahmad Abad Street, Mashhad, Iran; email: taghaviMR@mums.ac.ir
Uncontrolled Keywords: Hypothyroidism metformin polycystic ovarian syndrome (PCOS) thyrotropin (TSH) liothyronine placebo thyrotropin thyroxine article body mass clinical article controlled study disease association drug effect female human liothyronine blood level obesity ovary polycystic disease patient selection randomized controlled trial thyroid function thyroid function test thyrotropin blood level thyroxine blood level treatment duration treatment outcome Humans Hypoglycemic Agents Overweight Polycystic Ovary Syndrome Thyroid Gland Thyroid Hormones
Subjects: WK Endocrine System
WP Gynecology
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 30 Apr 2020 06:38
Last Modified: 30 Apr 2020 06:38
URI: http://eprints.mums.ac.ir/id/eprint/17067

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