Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran

Mosannen-Mozaffari, P. and Falaki, F. and Amirchaghmaghi, M. and Pakfetrat, A. and Dalirsani, Z. and Saghafi-khadem, S. (2010) Multifocal epithelial hyperplasia, a rare oral infection in Asia: Report of twelve cases in Iran. Medicina Oral, Patologia Oral y Cirugia Bucal, 15 (4). e591-e595.

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Objectives: Multifocal epithelial hyperplasia (MEH) is benign, asymptomatic oral disease with viral etiology. The frequency of this disease varies widely from one geographic region to another, and can vary, from 0.002 to 35 depending on the population studied. Study design: Here we report the clinicopathological features of twelve cases of MEH referred to Oral Medicine Department of Mashhad Dental School for the first time in Iran. Records of patients with the diagnosis of MEH in our department during 7 years were analyzed and data were extracted. Results: Most of the patients were younger than 20-year-old (66), and females were predominantly affected (7:12). The mean age of onset was 12.72±10.14 years and the mean duration was 52.54 ± 78.51 months. Patients had multiple, well circumscribed, soft, non tender, flattened papules, with a color similar to the adjacent mucosa, in different areas of the oral cavity but the most affected site was buccal mucosa. Familial history of such lesions was negative in all patients. Only three cases showed spontaneous regression. Conclusion: In spite of rare nature of this disease in Asia, it seems that it is not the case in Khorasan Province, southeast Iran. © Medicina Oral S. L.

Item Type: Article
Additional Information: Cited By :5 Export Date: 16 February 2020 Correspondence Address: Falaki, F.; Mashhad University of Medical Sciences, Oral Medicine Department, Research Center of Mashhad Dental School, Azadi SQR, Mashhad, Iran; email:
Uncontrolled Keywords: Case report Focal epithelial hyperplasia Heck's disease Human papilloma virus Iran Oral medicine adult age distribution article child clinical article disease duration epithelium hyperplasia female human human tissue male medical record mouth cavity mouth infection mouth mucosa multifocal epithelial hyperplasia papule remission retrospective study school child sex difference Adolescent Humans Retrospective Studies Young Adult
Subjects: WU Dentistry. Oral surgery
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 30 Apr 2020 08:12
Last Modified: 30 Apr 2020 08:12

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