Molecular epidemiology of fonsecaea species

Najafzadeh, M. J. and Sun, J. and Vicente, V. A. and Klaassen, C. H. W. and Bonifaz, A. and Gerrits van den Ende, A. H. G. and Menken, S. B. J. and Sybren de Hoog, G. (2011) Molecular epidemiology of fonsecaea species. Emerging Infectious Diseases, 17 (3). pp. 464-469.

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To assess population diversities among 81 strains of fungi in the genus Fonsecaea that had been identifi ed down to species level, we applied amplifi ed fragmentlength polymorphism (AFLP) technology and sequenced the internal transcribed spacer regions and the partial cell division cycle, β-tubulin, and actin genes. Many species of the genus Fonsecaea cause human chromoblastomycosis. Strains originated from a global sampling of clinical and environmental sources in the Western Hemisphere, Asia, Africa, and Europe. According to AFLP fi ngerprinting, Fonsecaea isolates clustered in 5 groups corresponding with F. pedrosoi, F. monophora, and F. nubica: the latter 2 species each comprised 2 groups, and F. pedrosoi appeared to be of monophyletic origin. F. pedrosoi was found nearly exclusively in Central and South America. F. monophora and F. nubica were distributed worldwide, but both showed substantial geographic structuring. Clinical cases outside areas where Fonsecaea is endemic were probably distributed by human migration.

Item Type: Article
Additional Information: Cited By :43 Export Date: 16 February 2020 CODEN: EIDIF Correspondence Address: Sybren de hoog, G.; Centraalbureau voor Schimmelcultures Fungal Biodiversity Centre, PO Box 85167, NL-3508 AD Utrecht, Netherlands; email:
Uncontrolled Keywords: beta actin beta tubulin internal transcribed spacer type II site specific deoxyribonuclease amplified fragment length polymorphism article bacterial strain cell division chromomycosis Fonsecaea Fonsecaea monophora Fonsecaea nubica Fonsecaea pedrosoi fungal strain fungus isolation geography migration multilocus sequence typing nonhuman phylogeny
Subjects: WA Public Health
QW Microbiology and Immunology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 30 Apr 2020 07:49
Last Modified: 30 Apr 2020 07:49

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