The effect of hydro alcoholic nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: A randomized double-blind control trial

Namazi, N. and Esfanjani, A. T. and Heshmati, J. and Bahrami, A. (2011) The effect of hydro alcoholic nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes: A randomized double-blind control trial. Pakistan Journal of Biological Sciences, 14 (15). pp. 775-779.

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Abstract

Type 2 diabetes is a metabolic disorder that is strongly associated with cardiovascular risk. Inflammation is a potential risk factor for cardiovascular disease. In this study, hydro alcoholic extract of Nettle (Urtica dioica) on insulin sensitivity and some inflammatory indicators in type 2 diabetic patients were studied. A randomized double-blind clinical trial on 50 men and women with type 2 diabetes was done for 8 weeks. Patients were adjusted by age, sex and duration of diabetes, then randomly divided into two groups, an intervention and control group. They received, 100 mg kg -1 nettle extract or placebo in three portions a day for 8 weeks. Interleukin 6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α), High Sensitive C-Reactive protein (hs-CRP) and Fasting Insulin concentration were measured. Insulin Sensitivity was calculated, at the beginning and the end of the study. The data were analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, IL-6 and hs-CRP showed a significant decrease in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has decreasing effects on IL-6 and hs-CRP in patients with type 2 diabetes after eight weeks intervention. © 2011 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Cited By :24 Export Date: 16 February 2020 Correspondence Address: Esfanjani, A. T.; Nutrition Research Center, Faculty of Health and Nutrition, Tabriz University of Medical Science, Attar Avenue, Golgasht Street, Tabriz, Iran
Uncontrolled Keywords: Complications Dabetes mellitus Inflammation Insulin Nettle Prevention biological marker C reactive protein interleukin 6 placebo plant extract article chemistry clinical trial controlled clinical trial controlled study double blind procedure female human insulin resistance male metabolism middle aged non insulin dependent diabetes mellitus pathophysiology randomized controlled trial Urtica dioica Biological Markers C-Reactive Protein Diabetes Mellitus, Type 2 Double-Blind Method Humans Interleukin-6 Placebos Plant Extracts
Subjects: WK Endocrine System
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 04 May 2020 04:50
Last Modified: 04 May 2020 04:50
URI: http://eprints.mums.ac.ir/id/eprint/17081

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