Investigating the metabolic effects of the cyclic nucleotide phosphodiesterase inhibitors on immature balb/c mice

Parizadeh, S. M. R. and Shafiee-Nick, R. and Sabery-Karimian, M. and Ghayour-Mobarhan, M. and Ferns, G. A. A. (2010) Investigating the metabolic effects of the cyclic nucleotide phosphodiesterase inhibitors on immature balb/c mice. Pakistan Journal of Nutrition, 9 (8). pp. 776-780.

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Abstract

We have investigated the metabolic effects of IBMX (3-isobutyl-1-methyl xanthine, a non-selective PDE inhibitor), amrinone, MC7 (6-(4-(tetrahydro-2H-pyran-4-yl)-4-oxobutoxy)-4-methylquinolin-2(1 H)-one) and MC9 (6-(4-(1-ethylpiperidin-4-yl)-4-oxobutoxy)-4-methylquinolin-2(1H)-one) (selective PDE3 inhibitors) on immature balb/c mice. Controls included groups of mice that received no intervention (control 1) and a group injected with 1mg/kg of drug carrier (control 2). The four experimental groups were weighed and injected separately with IBMX, amrinone, MC7 and MC9 (1mg/kg) daily for seven days after which they were killed and 59 blood and tissue samples were collected. The administration of drug carrier into the male mice, decreased the growth pattern during the second (P<0.05) and third (P<0.001) day. After the injection of drug carrier, there wasn't any significant difference between the growth pattern, and the concentrations of biochemical factors in the male, comparing with female mice. Therefore, a group of mice, including both male and female, was used. MC7 decreased the growth pattern on the day two (P<0.01). IBMX increased glucose (P<0.05), triglyceride (P<0.05) and glycogen (P<0.01) concentrations, whereas amrinone decreased the glucose (P<0.05) comparing with control 2. The ability of stress tolerating in immature female mice was more than that in the male mice. In spite of the similar inhibition influence, the experimental drugs used in this study, had different metabolic effects. © Asian Network for Scientific Information, 2010.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Ghayour-Mobarhan, M.; Director of New Science and Technology Department, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Postal Code: 9196773117, Iran
Uncontrolled Keywords: CAMP CGMP Cyclic nucleotide phosphodiesterases Growth pattern 6 4 (1 ethylpiperidin 4 yl) 4 oxobutoxy 4 methylquinolin 2(1h) one 6 4 (tetrahydro 2h pyran 4 yl) 4 oxobutoxy 4 methylquinolin 2(1h) one amrinone cholesterol glucose glycogen isobutylmethylxanthine mc 7 mc 9 phosphodiesterase inhibitor triacylglycerol unclassified drug animal experiment animal tissue article Bagg albino mouse blood sampling cholesterol blood level controlled study drug effect drug mechanism female glucose blood level glycogen liver level growth inhibition growth rate male mouse nonhuman sex difference triacylglycerol blood level Mus
Subjects: QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 30 Apr 2020 03:23
Last Modified: 30 Apr 2020 03:23
URI: http://eprints.mums.ac.ir/id/eprint/17091

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