Hormone receptor status in breast cancer and its relation to age and other prognostic factors

Pourzand, A. and Fakhree, M. B. A. and Hashemzadeh, S. and Halimi, M. and Daryani, A. (2011) Hormone receptor status in breast cancer and its relation to age and other prognostic factors. Breast Cancer: Basic and Clinical Research, 5 (1). pp. 87-92.

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Background: Increasing evidence shows the importance of young age, estrogen receptor (ER), progesterone receptor (PR) status, and HER-2 expression in patients with breast cancers. Patients and methods: We organized an analytic cross-sectional study of 105 women diagnosed with breast cancer who have been operated on between 2008 to 2010. We evaluated age, size, hormone receptor status, HER-2 and P53 expression as possible indicator of lymph node involvement. Results: There is a direct correlation between positive progesterone receptor status and being younger than 40 (P< 0.05). Also, compared with older women, young women had tumors that were more likely to be large in size and have higher stages (P< 0.05). Furthermore patients with negative progesterone receptor status were more likely to have HER-2 over expression (P< 0.05). The differences in propensity to lymph node metastasis between hormone receptor statuses were not statically significant. Conclusions: Although negative progesterone receptor tumors were more likely to have HER-2 over expression, it is possible that higher stage and larger size breast cancer in younger women is related to positive progesterone receptor status. © the author(s), publisher and licensee Libertas Academica Ltd.

Item Type: Article
Additional Information: Cited By :13 Export Date: 16 February 2020 Correspondence Address: Daryani, A.; Department of general Surgery, Imam Reza hospital, Tabriz University of Medical SciencesIran; email: dr.amirdaryani@gmail.com
Uncontrolled Keywords: Age Breast cancer Estrogen receptor Lymph node metastasis Progesterone receptor epidermal growth factor receptor 2 protein p53 adult article cancer staging cross-sectional study female gene overexpression human intraductal carcinoma invasive carcinoma major clinical study prognosis protein expression tumor volume
Subjects: WK Endocrine System
WP Gynecology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 29 Apr 2020 04:36
Last Modified: 29 Apr 2020 04:36
URI: http://eprints.mums.ac.ir/id/eprint/17092

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