Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals

Sabouri, A. H. and Saito, M. and Usuku, K. and Bajestan, S. N. and Mahmoudi, M. and Forughipour, M. and Sabouri, Z. and Abbaspour, Z. and Goharjoo, M. and Khayami, E. and Hasani, A. and Izumo, S. and Arimura, K. and Farid, R. and Osame, M. (2005) Differences in viral and host genetic risk factors for development of human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis between Iranian and Japanese HTLV-1-infected individuals. Journal of General Virology, 86 (3). pp. 773-781.

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Abstract

Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disease observed only in 1-2 of infected individuals. HTLV-1 provirus load, certain HLA alleles and HTLV-1 tax subgroups are reported to be associated with different levels of risk for HAM/TSP in Kagoshima, Japan. Here, it was determined whether these risk factors were also valid for HTLV-1-infected individuals in Mashhad in northeastern Iran, another region of endemic HTLV-1 infection. In Iranian HTLV-1-infected individuals (n=132, 58 HAM/TSP patients and 74 seropositive asymptomatic carriers), although HLA-DRB1*0101 was associated with disease susceptibility in the absence of HLA-A*02 (P=0.038; odds ratio=2.71) as observed in Kagoshima, HLA-A*02 and HLA-Cw*08 had no effect on either the risk of developing HAM/TSP or HTLV-1 provirus load. All Iranian subjects possessed tax subgroup A sequences, and the protective effects of HLA-A*02 were observed only in Kagoshima subjects with tax subgroup B but not in those with tax subgroup A. Both the prevalence of HTLV-1 subgroups and the host genetic background may explain the different risks levels for HAM/TSP development in these two populations. © 2005 SGM.

Item Type: Article
Additional Information: Cited By :50 Export Date: 16 February 2020 CODEN: JGVIA Correspondence Address: Saito, M.; Department of Neurology/Geriatrics, Kagoshima University, Grad. Sch. of Med./Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan; email: mineki@m3.kufm.kagoshima-u.ac.jp
Uncontrolled Keywords: HLA A2 antigen HLA C antigen HLA DR antigen Tax protein article controlled study disease predisposition endemic disease gene sequence genetic risk HLA system human Human T cell leukemia virus 1 Human T cell leukemia virus infection infection prevention Iran Japan nonhuman pathogenesis prevalence priority journal provirus risk assessment spastic paraplegia spinal cord disease virus cell interaction virus load Genetic Predisposition to Disease HLA-A Antigens Human T-lymphotropic virus 1 Humans Paraparesis, Tropical Spastic Risk Factors HTLV Irania Subgroup A Subgroup B
Subjects: WC Communicable Diseases
WH Hemic and Lymphatic System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 23 Apr 2020 09:27
Last Modified: 23 Apr 2020 09:27
URI: http://eprints.mums.ac.ir/id/eprint/17102

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