Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease

Sahebkar, A. (2011) Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World Journal of Gastroenterology, 17 (2). pp. 271-272.

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Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and its prevalence is likely to reach epidemic proportions. According to the "two-stage hypothesis" proposed for the pathophysiology of NAFLD, insulin resistance, oxidative stress and pro-in fammatory cytokines are among the key promoters of the disease. Here, ginger has been hypothesized to prevent NAFLD or blunt its progression via several mechanisms, such as sensitizing insulin effects, activating peroxisome prolifer-ator-activated receptor γ which induces adiponectin and down-regulates pro-inflammatory cytokines, changing the balance between adiponectin and tumor necrosis factor-α in favor of adiponectin, promoting considerable antioxidant effects and antidyslipidemic properties, and reducing hepatic triglyceride content which can prevent steatosis. The aforementioned mechanisms imply that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD. Therefore, conducting trials to explore its benefits in clinical practice is greatly recommended. © 2011 Baishideng. All rights reserved.

Item Type: Article
Additional Information: Cited By :37 Export Date: 16 February 2020 CODEN: WJGAF Correspondence Address: Sahebkar, A.; Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, PO Box 91775-1365, Mashhad, Iran; email: sahebkarah811@mums.ac.ir
Uncontrolled Keywords: Ginger Infammation Insulin resistance Nonalcoholic fatty liver disease Oxidative stress adiponectin antilipemic agent antioxidant cytokine ginger extract high density lipoprotein cholesterol low density lipoprotein cholesterol peroxisome proliferator activated receptor alpha peroxisome proliferator activated receptor gamma triacylglycerol tumor necrosis factor alpha cholesterol blood level clinical trial diet supplementation drug efficacy dyslipidemia human letter medicinal plant nonalcoholic fatty liver protein expression steatosis Antioxidants Fatty Liver Humans Inflammation Liver Plant Extracts PPAR gamma Prevalence Triglycerides
Subjects: WI Digestive System
QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 02 May 2020 05:07
Last Modified: 02 May 2020 05:07
URI: http://eprints.mums.ac.ir/id/eprint/17109

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