Correlation between catecholamine levels and outcome in patients with severe head trauma

Salehpoor, F. and Bazzazi, A. M. and Estakhri, R. and Zaheri, M. and Asghari, B. (2010) Correlation between catecholamine levels and outcome in patients with severe head trauma. Pakistan Journal of Biological Sciences, 13 (15). pp. 738-742.

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Abstract

Some studies have shown that catecholamines and the changes in their levels during and after head trauma can be useful in predicting the outcome in head trauma patients. The goal of this study is to search for a probable relation between urine levels of catecholamines and prognosis in patients with severe head trauma. Fifty four patients with severe head trauma Glasgow Coma Scale (GCS<8) on admission time were recruited in Imam Reza Hospital within one. These patients were included when having no major accompanying trauma in other organs. Twenty four hour urine was collected after admission and levels of metanephrine and nor-metanephrine were measured. The relation between urine levels of these metabolites with final outcome and also with GCS at admission, 24, 48 hand 1 week after admission and discharge time and Glasgow Outcome Scale (GOS) were studied. Fifty two patients, 48 males and 4 females with a mean age of 32.3±14.7 (3-72) years were included. The main underlying etiologies were motorcycle (46.2) and car accidents (25). Diffuse axonal injury, brain contusion and subdural hematoma were three main diagnoses (28.8, 17.3 and 15.4 of the cases, respectively). 19 (36.5) of the patients expired within the study period. The mean level of metanephrine and normetanephrine in urine were 207.9±200.5 and 330.2±218.4 jag in 24 h, respectively. There was no meaningful relation between urine levels of these metabolites and any of GCS and GOS. There was also no meaningful relation between these parameters and final prognosis in patients. © 2010 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 Correspondence Address: Bazzari, A. M.; Department of Neurosurgery, Tabriz University of Medical Sciences, Imam Reza Hospital, Tabriz, Iran
Uncontrolled Keywords: Brain contusion Glasgow coma scale Glasgow outcome scale Subdural hematoma Urine catecholamine catecholamine adolescent adult aged article brain injury female head injury human male middle aged prognosis treatment outcome urine Brain Injuries Catecholamines Craniocerebral Trauma Hematoma, Subdural Humans
Subjects: WL Nervous system
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 22 Apr 2020 07:12
Last Modified: 22 Apr 2020 07:12
URI: http://eprints.mums.ac.ir/id/eprint/17113

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