Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome

Sani, M. N. and Kianifar, H. R. and Kianee, A. and Khatami, G. (2006) Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome. World Journal of Gastroenterology, 12 (15). pp. 2427-2431.

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Abstract

Aim: To study the effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome. Methods: Garlic powder in a cap sule form was given to 15 children with hepatopulmonary syndrome (confirmed by contrast echocardiography) at the dosage of 1 g/1.73 m2 per day. Patients were evaluated clinically and by arterial blood gas every four weeks. Results: The garlic capsule was administered to 15 patients with hepatopulmonary syndrome. There were 10 boys and 5 girls with a mean age of 9.4 ± 3.9 years. The underlying problems were biliary tract atresia (4 patients), autoimmune hepatitis (4 patients), cryptogenic cirrhosis (4 patients) and presinusoidal portal hypertension (3 patients). Eight patients (53.3) showed an increase of 10 mmHg in their mean arterial oxygen pressure. The baseline PaO2 was 65.6 ± 12.1 mmHg in the responder group and 47.1 ± 11.2 mmHg in non-responder group. At the end of treatment the mean PaO2 in responders and non-responders was 92.2 ± 7.75 mmHg and 47.5 ± 11.87 mmHg, respectively (P < 0.01). Conclusion: Garlic may increase oxygenation and improve dyspnea in children with hepatopulmonary syndrome. © 2006 The WJG Press. All rights reserved.

Item Type: Article
Additional Information: Cited By :27 Export Date: 16 February 2020 CODEN: WJGAF Correspondence Address: Kianifar, H.R.; Department of Pediatrics, Ghaem Medical Center, Mashhad University of Medical Sciences, Ahmadabad Ave., Mashhad, Iran; email: hr-kianifar@Mums.Ac.ir
Uncontrolled Keywords: Arterial oxygen pressure Garlic Hepatopulmonary syndrome Pediatric garlic extract adolescent arterial oxygen tension article autoimmune hepatitis bile duct atresia child clinical article contrast echocardiography controlled study disease duration drug capsule drug dose regimen drug mechanism dyspnea female human liver cirrhosis liver transplantation male oxygenation portal hypertension powder scoring system statistical analysis statistical significance
Subjects: WI Digestive System
WS Pediatrics
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 23 Apr 2020 19:24
Last Modified: 23 Apr 2020 19:24
URI: http://eprints.mums.ac.ir/id/eprint/17115

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