Evaluation of long-term usage of low dose doxycycline after periodontal surgery in patients with chronic periodontitis

Sargolzaei, N. and Arab, H. R. and Moeintaghavi, A. and Ghanbari, H. and Rigi, A. and Hoshyar, M. H. (2006) Evaluation of long-term usage of low dose doxycycline after periodontal surgery in patients with chronic periodontitis. International Journal of Pharmacology, 2 (4). pp. 467-470.

[img] Text
Evaluation of long-term usage of low dose doxycycline after periodontal surgery in patients with chronic periodontitis.pdf

Download (205kB)
[img] Text
467-470.pdf

Download (205kB)

Abstract

The major aim of periodontal treatment is reconstruction of broken tissues and maintenance of periodontal health. Different chemotherapeutic agents are used to change the host response to bacterial irritants along with nonsurgical and surgical periodontal therapies. Doxycycline is one of these agents used widely due to its anticollagenolytic and antibacterial properties. The aim of this study was to evaluate the effect of long-term usage of low dose doxycycline after periodontal surgery in the treatment of chronic periodontitis. In this study, 30 patients with chronic periodontitis were selected. After initial therapy and periodontal surgery, all patients were recalled and Probing Depth (PD), Attachment Level (AL) and Bleeding on Probing (BOP) indices were measured. Then they randomly allocated to test and control groups. In the test group (15 patients) all patients received 90 capsules (20 mg doxycycline) to use one cap per day for the following 3 month. The controls received the same shape and color placebo capsules. All the patients were recalled after one and 3 month and the above mentioned parameters were recorded again. The results showed significant reduction in PD and AL in the test group. Bop did not change significantly in both groups. PD and CAL increased in the control group but these increases were significant only for PD. The results of this study showed that the use of low dose doxycycline along with supportive periodontal treatment and oral hygiene during maintenance period can improve the clinical parameters. © 2006 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Moeintaghavi, A.; Department of Periodontics, Dental Research Center, Mashhad University of Medical Sciences, Vakilabad Blvd., Mashad, Iran
Uncontrolled Keywords: Antibiotic therapy Chronic periodontitis Low dose doxycycline Maintenance Periodontal surgery Supportive treatment amoxicillin cocodamol doxycycline placebo adjuvant therapy adult article clinical article clinical trial controlled clinical trial controlled study dental surgery double blind procedure drug use female human long term care low drug dose maintenance therapy male mouth hygiene periodontitis postoperative care randomized controlled trial statistical significance
Subjects: WU Dentistry. Oral surgery
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 26 Apr 2020 17:43
Last Modified: 26 Apr 2020 17:43
URI: http://eprints.mums.ac.ir/id/eprint/17117

Actions (login required)

View Item View Item