Common Carotid Artery Intima-Media Thickness and atherosclerotic plaques in carotid bulb in patients with Chronic Kidney Disease on hemodialysis: A Case-control study

Shakeri, A. and Abdi, M. and Khosroshahi, H. T. and Fouladi, R. F. (2011) Common Carotid Artery Intima-Media Thickness and atherosclerotic plaques in carotid bulb in patients with Chronic Kidney Disease on hemodialysis: A Case-control study. Pakistan Journal of Biological Sciences, 14 (17). pp. 844-848.

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Abstract

The Common Carotid artery Intima-Media Thickness (CCIMT) can reflect systemic atherosclerosis in renal patients on hemodialysis. This study aimed to compare CCIMT measured by color Doppler ultrasonography between two groups including dialytic patients and normal subjects. In this case-control setting, 48 patients with Chronic Kidney Disease (CKD) on hemodialysis (case group) and 46 age and sex-matched healthy subjects (control group) were enrolled in this study. Color Doppler ultrasound was used to measure CCIMT and determine presence of atherosclerotic plaques in carotid bulb in both groups. Various laboratory parameters were also determined. Serum levels of triglyceride, total cholesterol, low-density lipoprotein, fasting sugar, ionized calcium, inorganic phosphorus and magnesium were comparable between the two groups. Hypertension and elevated levels of serum C-reactive protein, as well as the mean levels of serum non-fasting homocysteine and phosphate were significantly higher in the case group. Mean levels of serum high-density lipoprotein and albumin were significantly higher in the controls. Mean maximum CCIMT was significantly higher in the case group than in controls (0.73±0.15 vs. 0.68±0.08 mm, p = 0.01) even after adjusting for other confounding variables. Frequency of patients with atherosclerotic plaques in carotid bulbs was not significantly different between case and controls. In conclusion, this study showed that CCIMT is significantly higher in CKD patients on hemodialysis comparing with matched normal counterparts. Furthermore, this difference was independent of other conventional risk factors for atherosclerosis. © 2011 Asian Network for Scientific Information.

Item Type: Article
Additional Information: Cited By :16 Export Date: 16 February 2020 Correspondence Address: Fouladi, R. F.; Department of Radiology, Tabriz University of Medical Sciences, Imam Reza Hospital, Tabriz, Iran
Uncontrolled Keywords: Atherosclerosis Chronic kidney dsease Color doppler ultrasound Intima-media thickness Risk factor C reactive protein aged arterial wall thickness article atherosclerotic plaque blood analysis case control study chronic kidney failure common carotid artery echography human hypertension Iran male metabolism middle aged pathology pathophysiology renal replacement therapy Blood Chemical Analysis C-Reactive Protein Carotid Artery, Common Carotid Intima-Media Thickness Case-Control Studies Humans Plaque, Atherosclerotic Renal Dialysis Renal Insufficiency, Chronic Risk Factors
Subjects: WJ Urogenital System
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 22 Apr 2020 04:46
Last Modified: 22 Apr 2020 04:46
URI: http://eprints.mums.ac.ir/id/eprint/17121

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