Factors Related to Seizure in Tramadol Poisoning and Its Blood Concentration

Taghaddosinejad, F. and Mehrpour, O. and Afshari, R. and Seghatoleslami, A. and Abdollahi, M. and Dart, R. C. (2011) Factors Related to Seizure in Tramadol Poisoning and Its Blood Concentration. Journal of Medical Toxicology, 7 (3). pp. 183-188.

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This study examines the relation between seizure and plasma tramadol concentration in patients with tramadol poisoning, as a novel centrally acting analgesic used for the treatment of mild to severe pain. All patients admitted with a history of tramadol overdose accompanied by unconsciousness or seizures referred to Baharloo Hospital Poison Center, Tehran, Iran from March 2008 to March 2009 were included. Demographic information, clinical findings, and blood tramadol concentrations were studied. There were 401 patients with a history of tramadol overdose; 121 (30. 2) with a history of seizure and 14 (3. 5) with a history of unconsciousness were included. Most of overdoses involved men (83). The mean age was 22. 9 years (range, 14-50 years). Intentional overdose was the most common mode of poisoning (51. 9). The mean dose ingested was 1,511 mg (SD, 1,353; range, 200-7,000). Mean back-extrapolated tramadol blood concentrations were 3,843 ng/mL (3,715; 269-20,049). Back-extrapolated blood concentrations were correlated with dose (r = 0. 313; P < 0. 001) as well as blood concentration levels (r = 0. 801; P < 0. 001). Seizure was significantly correlated to higher reported dose (P < 0. 001) and tramadol only to overdose (P < 0. 001). However, it was neither related to higher tramadol blood concentrations, nor related to time elapsed, age, sex, history of addiction, and observed Glasgow Coma Scale of patients. Most patients experienced just one seizure (76). The tramadol-induced seizure is dose dependent. Although higher doses of tramadol was related to higher blood concentration, blood tramadol concentrations was not associated with seizure. © 2011 American College of Medical Toxicology.

Item Type: Article
Additional Information: Cited By :60 Export Date: 16 February 2020 Correspondence Address: Mehrpour, O.; Department of Clinical Toxicology and Forensic Medicine, Faculty of Medicine, Birjand University of Medical Sciences, Ghaffari Avenue, Birjand, Iran; email: omehrpour@razi.tums.ac.ir
Uncontrolled Keywords: Blood concentration Poisoning Seizure Tramadol adolescent adult article child dose response drug abuse drug blood level drug intoxication drug overdose female Glasgow coma scale human Iran major clinical study male medical history opiate addiction pain poison center school child self poisoning substance abuse unconsciousness Age Factors Analgesics, Opioid Chromatography, Gas Dose-Response Relationship, Drug Humans Middle Aged Overdose Prospective Studies Seizures Sex Factors Young Adult
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 28 Apr 2020 04:22
Last Modified: 28 Apr 2020 04:22
URI: http://eprints.mums.ac.ir/id/eprint/17129

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