Antiproliferative effects of extracts from Iranian Artemisia species on cancer cell lines

Taghizadeh Rabe, S. Z. and Mahmoudi, M. and Ahi, A. and Emami, S. A. (2011) Antiproliferative effects of extracts from Iranian Artemisia species on cancer cell lines. Pharmaceutical Biology, 49 (9). pp. 962-969.

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Abstract

Objective: Different species of Artemisia (Asteraceae) have shown to exhibit antitumor activity. The aim of this study was to identify the antiproliferative effect of some Artemisia species from Iran on cultured human cancer cells. Materials and methods: Methanol, ethyl acetate, dichloromethane and n-hexane extracts from aerial parts of seven species of Artemisia were prepared and their antiproliferative effects on four cancer (AGS, HeLa, HT-29 and MCF-7) and normal cell line (L929) were determined. Different concentrations of extracts were added to cultured cells and incubated for 72 h. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was employed to assess the cell viability. Results: Different extracts exert various growth inhibitory effects. In case of AGS cells, dichloromethane and methanol extracts of A. ciniformis Krasch. & Popov ex Poljak. (IC50 values: 35 and 60 μg/ml, respectively) showed the highest growth inhibitory effects. HeLa cells were more sensitive to both A. diffusa Krasch. ex Poljak. dichloromethane (IC50 value: 71 μg/ml) and A. ciniformis ethylacetate (IC50 value: 73 μg/ml) extracts. Dichloromethane extracts of A. diffusa, A. santolina Schrenk and A. ciniformis (IC50 values: 42, 91 and 94 μg/ml, respectively) exhibited more inhibition on HT-29 cells in comparison to other extracts. MCF-7 cells were best inhibited by A. ciniformis dichloromethane (IC50 value: 29 μg/ml) and A. vulgaris L. ethyl acetate (IC50 value: 57 μg/ml) extracts. Discussion and conclusion: This study shows the antiproliferative effects of Artemisia extracts on malignant cell lines. Artemisia could be also considered as a promising chemotherapeutic agent in cancer treatment. © 2011 Informa Healthcare USA, Inc.

Item Type: Article
Additional Information: Cited By :43 Export Date: 16 February 2020 CODEN: PHBIF Correspondence Address: Emami, S.A.; Department of Pharmacognosy, School of Pharmacy, Ferdowsi University, Vakil-Abad Blvd, Mashhad, Iran; email: emamia@mums.ac.ir
Uncontrolled Keywords: AGS HeLa HT-29 MCF-7 MTT assay 3 (4,5 dimethyl 2 thiazolyl) 2,5 diphenyltetrazolium bromide acetic acid ethyl ester angiogenesis inhibitor antimetastatic agent antimitotic agent antineoplastic agent Artemisia biennis extract Artemisia ciniformis extract Artemisia diffusa extract Artemisia santolina extract Artemisia vulgaris extract dichloromethane hexane methanol plant extract unclassified drug animal cell antineoplastic activity Artemisia Artemisia biennis Artemisia ciniformis Artemisia diffusa Artemisia santolina article cancer inhibition cell strain HT29 cell strain L 929 cell strain MCF 7 cell viability chemosensitivity concentration response controlled study drug effect HeLa cell human human cell IC 50 Iran mouse nonhuman Antineoplastic Agents Cell Line Cell Proliferation Drug Screening Assays, Antitumor HeLa Cells HT29 Cells Humans Phytotherapy Plant Components, Aerial Plant Extracts Tumor Cells, Cultured Artemisia vulgaris Asteraceae
Subjects: QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 19 Apr 2020 06:11
Last Modified: 19 Apr 2020 06:11
URI: http://eprints.mums.ac.ir/id/eprint/17132

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