Comparison of oral zinc sulfate with systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis

Yazdanpanah, M. J. and Banihashemi, M. and Pezeshkpoor, F. and Khajedaluee, M. and Famili, S. and Tavakoli Rodi, I. and Yousefzadeh, H. (2011) Comparison of oral zinc sulfate with systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis. Dermatology Research and Practice, 2011.

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Abstract

The purpose of this study was to investigate comparison between oral zinc sulfate and meglumine antimoniate in the treatment of cutaneous leishmaniasis (CL). So 100 patients with CL were included and randomly divided into two groups. The first group was treated with oral zinc sulfate (10 mg/kg/day during 45 days period), and the second group was treated with systemic meglumine antimoniate (20 mg/kg/day intramuscularly for 20 days). Acceptable cure after completing 45 days of followup occurred in 30.2 of lesions in first group, while this was 35.5 for the second group. There is not any significant difference between the two treatment groups (P = 0.42). Serious side effects resulting in treatment discounting occurred in only meglumine antimoniate group. Although cure rate of systemic meglumine antimoniate group was better the treatment with zinc sulfate is much easier, cheaper, more convenient in consumption, safer, and nearly close cure percentage to systemic meglumine antimoniate injections without serious side effect. © 2011 Mohamad Javad Yazdanpanah et al.

Item Type: Article
Additional Information: Cited By :9 Export Date: 16 February 2020 Correspondence Address: Banihashemi, M.; Research Center for Skin Disease and Cutaneous Leishmaniasis, Ghaem Hospital, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran; email: banihashemim@mums.ac.ir
Subjects: WC Communicable Diseases
WR Dermatology
Divisions: Mashhad University of Medical Sciences
Depositing User: mr lib7 lib7
Date Deposited: 01 Mar 2020 04:54
Last Modified: 01 Mar 2020 04:54
URI: http://eprints.mums.ac.ir/id/eprint/17147

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