Neuregulin1 types mRNA level changes in autism spectrum disorder, and is associated with deficit in executive functions

Abbasy, S. and Shahraki, F. and Haghighatfard, A. and Qazvini, M. G. and Rafiei, S. T. and Noshadirad, E. and Farhadi, M. and Rezvani asl, H. and Shiryazdi, A. A. and Ghamari, R. and Tabrizi, Z. and Mehrfard, R. and Esmaili kakroudi, F. and Azarnoosh, M. and Younesi, F. and Parsamehr, N. and Garaei, N. and Abyari, S. and Salehi, M. and Gholami, M. and Zolfaghari, P. and Bagheri, S. M. and Pourmehrabi, M. and Rastegarimogaddam, E. and Nobakht, E. and Nobakht, E. and Partovi, R. (2018) Neuregulin1 types mRNA level changes in autism spectrum disorder, and is associated with deficit in executive functions. EBioMedicine, 37. pp. 483-488.

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Abstract

Background: Autism spectrum disorder (ASD) is a pediatric heterogeneous psychiatric and neurodevelopmental disorder with social and communication deficits, language impairment and ritualistic or repetitive behaviors. ASD has significant genetic bases but candidate genes and molecular mechanisms of disorder are not clarified. Neuregulin1 (NRG1) gene, located in 8p12 is involved in development of central nervous system and was indicated as candidate gene in schizophrenia. Methods: mRNA level of types I, II and III of NRG1 gene were studied in peripheral blood of 1540 ASD patients (IQ > 70) and 1490 control children by quantitative Real Time PCR. Also three domains of executive functions (working memory, response inhibition and vigilance) were examined in all subjects. Findings: All three types were significantly down regulated in ASD patients. Significant deficiencies in executive functions (EF) were found in ASD patients. EF deficiencies mostly were associated with down expression of mRNA level of types I and III. Also correlations were found between NRG1 expression with gender and severity of ASD symptoms. Interpretations: Findings primarily have been suggested involvement of NRG1 in etiology of ASD. Also correlation of NRG1 mRNA level with EF deficiencies could shed lights on EF mechanisms and may suggest targeted treatments to improve particular executive functions. Fund: Young researchers and elites club funded the project due to the annual grant of special talents of Club that gave to Arvin Haghighatfard. © 2018 The Authors

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Correspondence Address: Haghighatfard, A.; Department of Biology, North Tehran Branch, Islamic Azad UniversityIran; email: a.haghighatfard@iautnb.ac.ir
Uncontrolled Keywords: Autism spectrum disorder Executive functions Gene expression NRG1 neu differentiation factor messenger RNA NRG1 protein, human alertness Article auditory attention quotient auditory response control quotient autism Autism Diagnostic Observation Schedule Cambridge neuropsychological test automated battery child cognition cognition assessment cognitive defect continuous performance test controlled study disease association disease severity down regulation DSM-5 executive function female gender gene human integrated visual and auditory continuous performance test major clinical study male mRNA expression level neuropsychological test NRG1 gene priority journal real time polymerase chain reaction response inhibition reverse transcription polymerase chain reaction schizophrenia school child spatial working memory visual attention quotient visual response control quotient working memory blood clinical trial gene expression regulation Humans Neuregulin-1 Real-Time Polymerase Chain Reaction RNA, Messenger
Subjects: WM Psychiatry
WS Pediatrics
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 10 Jun 2020 06:36
Last Modified: 10 Jun 2020 06:36
URI: http://eprints.mums.ac.ir/id/eprint/17158

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