Genetic and molecular origins of colorectal Cancer among the Iranians: An update

Abbaszadegan, M. R. and Moghbeli, M. (2018) Genetic and molecular origins of colorectal Cancer among the Iranians: An update. Diagnostic Pathology, 13 (1).

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Genetic and molecular origins of colorectal Cancer among the Iranians An update.pdf

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Background: Colorectal cancer (CRC) is one the leading causes of cancer related deaths among Iranians. Despite the various progresses in new therapeutic methods, it has still a low rate of survival. This high ratio of mortality is mainly related to the late diagnosis, in which the patients refer for treatment in advanced stages of tumor. Main body: colorectal cancer progression is largely associated with molecular and genetic bases. Although Iran has a high ratio of CRC mortality, there is not an efficient genetic panel for detection and prognosis. Therefore, it is critical to introduce new diagnostic markers with ability to detect in early stages. Conclusion: Present review summarizes all of the genetic and epigenetic factors which are reported in CRC until now among the Iranian patients to pave the way of incorporation of new ethnic specific markers into the clinical practice and development of new targeted therapeutic methods. © 2018 The Author(s).

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Moghbeli, M.; Mashhad University of Medical Sciences, Department of Modern Sciences and Technologies, Faculty of MedicineIran; email:
Uncontrolled Keywords: Colorectal Cancer Diagnosis Genetic Iran Marker tumor marker Arab cell transformation colorectal tumor epidemiology ethnology genetic epigenesis genetic predisposition genetics human molecular diagnosis pathology phenotype predictive value prognosis risk factor Arabs Biomarkers, Tumor Cell Transformation, Neoplastic Colorectal Neoplasms Epigenesis, Genetic Genetic Predisposition to Disease Humans Molecular Diagnostic Techniques Predictive Value of Tests Risk Factors
Subjects: WI Digestive System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 10 Jun 2020 06:39
Last Modified: 10 Jun 2020 06:39

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