WNT and NOTCH signaling pathways as activators for epidermal growth factor receptor in esophageal squamous cell carcinoma

Abbaszadegan, M. R. and Riahi, A. and Forghanifard, M. M. and Moghbeli, M. (2018) WNT and NOTCH signaling pathways as activators for epidermal growth factor receptor in esophageal squamous cell carcinoma. Cellular and Molecular Biology Letters, 23 (1).

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Abstract

Background: Esophageal squamous cell carcinoma (ESCC) is the most common histological type of esophageal cancer, with a poor prognosis. Deregulation of WNT and NOTCH signaling pathways is important in ESCC progression, which can be due to either malfunction of their components or crosstalk with other pathways. Therefore, identification of new crosstalk between such pathways may be effective to introduce new strategies for targeted therapy of cancer. A correlation study was performed to assess the probable interaction between growth factor receptors and WNT/NOTCH pathways via the epidermal growth factor receptor (EGFR) and Musashi1 (MSI1), respectively. Methods: Levels of MSI1/EGFR mRNA expression in tumor tissues from 48 ESCC patients were compared to their corresponding normal tissues using real-time polymerase chain reaction. Results: There was a significant correlation between EGFR and MSI1 expression (p = 0.05). Moreover, there was a significant correlation between EGFR/MSI1 expression and grade of tumor differentiation (p = 0.02). Conclusion: This study confirms a direct correlation between MSI1 and EGFR and may support the important role of MSI1 in activation of EGFR through NOTCH/WNT pathways in ESCC. © 2018, The Author(s).

Item Type: Article
Additional Information: Cited By :4 Export Date: 16 February 2020 CODEN: CMBLF Correspondence Address: Moghbeli, M.; Department of Modern Sciences and Technologies, Faculty of Medicine, Mashhad University of Medical SciencesIran; email: Meysammoghbeli@yahoo.com
Uncontrolled Keywords: Early stage Growth factor NOTCH Survival WNT epidermal growth factor receptor messenger RNA musashi 1 Notch receptor RNA binding protein unclassified drug Wnt protein EGFR protein, human MSI1 protein, human nerve protein adult aged Article cancer staging clinical article controlled study correlation analysis correlational study esophageal squamous cell carcinoma female gene expression gene overexpression human human cell human tissue lymph node metastasis male middle aged Notch signaling real time polymerase chain reaction tumor differentiation tumor invasion tumor volume Wnt signaling enzyme activation esophagus tumor gene expression regulation genetics metabolism pathology signal transduction squamous cell carcinoma Carcinoma, Squamous Cell Esophageal Neoplasms Gene Expression Regulation, Neoplastic Humans Nerve Tissue Proteins Receptor, Epidermal Growth Factor Receptors, Notch RNA-Binding Proteins Wnt Signaling Pathway
Subjects: WI Digestive System
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 10 Jun 2020 06:43
Last Modified: 10 Jun 2020 06:43
URI: http://eprints.mums.ac.ir/id/eprint/17160

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