Comparison of serum vitamin a levels between neonates with congenital heart disease and controls

Abtahi, S. and Mostafavian, Z. and Behnam, B. and Shaye, Z. A. (2018) Comparison of serum vitamin a levels between neonates with congenital heart disease and controls. Asian Journal of Pharmaceutical and Clinical Research, 11 (10). pp. 130-132.

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Abstract

Objective: Prevention of congenital heart disease (CHD) has been hampered by a lack of information about the known modifiable risk factors for abnormalities in cardiac development. Vitamin A plays an important role in the periods of rapid cellular growth and differentiation, especially during pregnancy. Assuming a link between Vitamin A levels and congenital malformations, hypothetical different levels of Vitamin A were evaluated in neonates with and without CHD, in this study. Methods: In a case–control study that was conducted in 2015 in Mashhad/Iran, serum levels of Vitamin A in 30 neonates with CHD were compared to 30 healthy controls. The cases were diagnosed by echocardiography and recruited by convenience sampling. Demographic and laboratory data including age, sex, and serum Vitamin A level in each group were collected. Data analysis was done in SPSS V 20 software, and descriptive statistics, t-test, and analysis of covariance were used. Results: The mean age in cases was 11±3.4 days and in controls was 12.5±4.8 days. A total of 18 patients (60) were male. In CHD patients, 10 cases (33.3) had cyanotic heart disease, and 20 cases (66.7) had non-cyanotic heart disease. The mean serum Vitamin A values in subjects (11.54±9.56 µg/dL) and controls (21.84±14.3 µg/dL) were significantly different, (p<0.05) and in case group was lower than the normal range. Conclusion: There was a significant difference in serum Vitamin A values in subjects and controls. Therefore, awareness of people about the importance of this vitamin in preventing CHD in children seems necessary. © 2018 The Authors. Published by Innovare Academic Sciences Pvt Ltd.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Mostafavian, Z.; Department of Community Medicine, Mashhad Branch, Islamic Azad UniversityIran; email: dr.mostafavian@mshdiau.ac.ir
Uncontrolled Keywords: Congenital heart disease Neonate Vitamin A
Subjects: WG Cardiovascular System
WS Pediatrics
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 Jun 2020 06:29
Last Modified: 09 Jun 2020 06:29
URI: http://eprints.mums.ac.ir/id/eprint/17167

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