Recent advances in co-delivery systems based on polymeric nanoparticle for cancer treatment

Afsharzadeh, M. and Hashemi, M. and Mokhtarzadeh, A. and Abnous, K. and Ramezani, M. (2018) Recent advances in co-delivery systems based on polymeric nanoparticle for cancer treatment. Artificial Cells, Nanomedicine and Biotechnology, 46 (6). pp. 1095-1110.

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Abstract

Cancer is a broad term for a class of prevalent diseases as one in three people develop cancer during their lifetime. Although, there are few success stories of cancer therapy, most of the existing medications do not lead to complete recovery. Because of the complexity of cancer, usually a single therapeutic approach is insufficient for the suppression of cancer growth and metastasis. Simultaneous loading and co-delivery of different agents with different physiochemical characteristics to the same tumors have been suggested for minimizing the dose of anticancer drugs and achieving the synergistic therapeutic impacts in cancers treatment. Intense work to develop nanotechnology-based systems as a suitable option for cancer treatment is currently underway. The purpose of this review is to provide an overview of the co-delivery systems based on polymeric nanoparticles including polymeric micelles, dendrimers, poly-d,l-lactide-co-glycolide, polyethylenimine, poly(l-lysine) and chitosan for efficacious cancer therapy. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Cited By :21 Export Date: 16 February 2020 Correspondence Address: Ramezani, M.; Department of Pharmaceutical Biotechnology, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical SciencesIran; email: ramezanim@mums.ac.ir
Uncontrolled Keywords: cancer therapy Co-delivery drug delivery gene delivery polymeric nanoparticles Amino acids Controlled drug delivery Drug dosage Gene therapy Gene transfer Nanoparticles Oncology Organic polymers Targeted drug delivery Co deliveries Nanotechnology based systems Polyethylenimines Polymeric micelle Therapeutic impact Diseases antineoplastic agent chitosan copolymer dendrimer drug carrier nanocarrier nanoparticle polyethyleneimine polyglactin polylysine polymer drug delivery system human nanotechnology physical chemistry polymerization Review chemistry drug combination micelle nanomedicine neoplasm trends Antineoplastic Agents Antineoplastic Combined Chemotherapy Protocols Drug Carriers Drug Combinations Drug Delivery Systems Humans Micelles Neoplasms Polymers
Subjects: QU Biochemistry
QV pharmacology
QZ pathology-neoplasms-Genetics
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 10 Jun 2020 04:36
Last Modified: 10 Jun 2020 04:36
URI: http://eprints.mums.ac.ir/id/eprint/17170

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