Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

Aliasghari, F. and Izadi, A. and Jabbari, M. and Imani, B. and Gargari, B. P. and Asjodi, F. and Ebrahimi, S. (2018) Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients? Journal of Medical Biochemistry, 37 (4). pp. 470-475.

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Abstract

Background: Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of insulin resistance, is the most common cause of chronic liver. The present study aimed to investigate the roles of vaspin and omentin-1 in the NAFLD-related pathology including IR, inflammation and elevated blood pressure. Methods: This cross-sectional study was conducted among 83 NAFLD patients in Jahrom, Iran. Plasma levels of omentin-1, vaspin, hs-CRP and IL-6 were measured. Anthropometric indices, lipid profiles, liver enzymes as well as abdominal ultrasonography were assessed. Results: Partial correlations controlling for age and sex showed significant positive correlation between vaspin and fasting blood sugar (FBS), insulin, HOMA-IR, and hs-CRP. It has been observed that omentin negatively correlated with glucose levels. Moreover, a marginally significant association has been found between omentin levels and systolic blood pressure (SBP). Conclusions: This study shows that vaspin and omentin-1 are associated with inflammation, insulin resistance and serum glucose levels in patients with NAFLD. © 2018 Fereshteh Aliasghari et al., published by Sciendo.

Item Type: Article
Additional Information: Cited By :2 Export Date: 16 February 2020 Correspondence Address: Ebrahimi, S.; School of Exercise and Nutrition Science, Faculty of Health Science, Deakin UniversityAustralia; email: saraebrahimi123@gmail.com
Uncontrolled Keywords: adipokines inflammation insulin resistance lipid profiles NAFLS adipocytokine alanine aminotransferase aspartate aminotransferase C reactive protein cholesterol glucose high density lipoprotein high sensitivity C reactive protein insulin interleukin 6 liver enzyme low density lipoprotein omentin 1 protein protein triacylglycerol unclassified drug vaspin Article blood pressure body height body mass body weight cholesterol blood level cross-sectional study diastolic blood pressure echography elevated blood pressure enzyme blood level fasting female glucose blood level glucose level homeostasis model assessment human insulin sensitivity major clinical study male nonalcoholic fatty liver physical activity Quantitative Insulin Sensitivity Check Index systolic blood pressure waist circumference waist hip ratio
Subjects: WI Digestive System
WK Endocrine System
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 08 Jun 2020 09:46
Last Modified: 08 Jun 2020 09:46
URI: http://eprints.mums.ac.ir/id/eprint/17179

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