Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

Aliasghari, F. and Izadi, A. and Jabbari, M. and Imani, B. and Gargari, B. P. and Asjodi, F. and Ebrahimi, S. (2018) Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients? Journal of Medical Biochemistry. pp. 1-6.

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Abstract

Background: Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of insulin resistance, is the most common cause of chronic liver. The present study aimed to investigate the roles of Vaspin and omentin-1 in the NAFLD-related pathology including IR, inflammation and elevated blood pressure. Methods: This cross-sectional study was conducted among 83 NAFLD patients in Jahrom, Iran. Plasma levels of omentin-1, Vaspin, hs-CRP and IL-6 were measured. Anthropometric indices, lipid profiles, liver enzymes as well as abdominal ultrasonography were assessed. Results: Partial correlations controlling for age and sex showed significant positive correlation between Vaspin and fasting blood sugar (FBS), insulin, HOMA-IR, and hs-CRP. It has been observed that omentin negatively correlated with glucose levels. Moreover, a marginally significant association has been found between Omentin levels and systolic blood pressure (SBP). Conclusions: This study shows that Vaspin and Omentin-1 are associated with inflammation, insulin resistance and serum glucose levels in patients with NAFLD. © 2018 Fereshteh Aliasghari et al., published by De Gruyter Open 2018.

Item Type: Article
Additional Information: Cited By :1 Export Date: 16 February 2020 Article in Press Correspondence Address: Ebrahimi, S.; School of Exercise and Nutrition Science, Faculty of Health Science, Deakin UniversityAustralia; email: saraebrahimi123@gmail.com
Uncontrolled Keywords: adfipokines inflammation insulin resistance lipid profiles NAFLS
Subjects: WG Cardiovascular System
WK Endocrine System
QU Biochemistry
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 Jun 2020 04:53
Last Modified: 09 Jun 2020 04:53
URI: http://eprints.mums.ac.ir/id/eprint/17180

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