Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38

Alibolandi, M. and Amel Farzad, S. and Mohammadi, M. and Abnous, K. and Taghdisi, S. M. and Kalalinia, F. and Ramezani, M. (2018) Tetrac-decorated chitosan-coated PLGA nanoparticles as a new platform for targeted delivery of SN38. Artificial Cells, Nanomedicine and Biotechnology, 46 (sup2). pp. 1003-1014.

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Abstract

New integrin-targeted nanoparticles made of chitosan-stabilized PLGA matrix was developed to specifically target colon adenocarcinoma. To this aim, SN38-encapsulated chitosan-coated PLGA NPs were conjugated with tetrac for integrin receptor-guided delivery. To provide a sustained release pattern for SN38, it was loaded into nanoparticles using single emulsion method. The size of NPs were 174.23 ± 6.12 nm with drug encapsulation efficiency and loading content of 73.16 ± 11.15 and 4.45 ± 0.31, respectively. The in vitro results confirmed that the designed nanoplatform showed specific cellular uptake and cytotoxicity in integrin overexpressing cancer cells and provided a sustained release profile for SN38. Additionally, an increased therapeutic potency of targeted formulation over both non-targeted and free drug was shown in vivo. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: Export Date: 16 February 2020 Correspondence Address: Alibolandi, M.; Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical SciencesIran; email: alibolandim@mums.ac.ir
Uncontrolled Keywords: chitosan integrin PLGA SN38 targeted delivery Tetrac Controlled drug delivery Drug products Emulsification Encapsulation Nanoparticles Integrins Targeted drug delivery chitosan nanoparticle firtecan integrin receptor polyglactin tetraiodothyroacetic acid thyroid hormone unclassified drug antineoplastic agent camptothecin drug carrier nanoparticle thyroxine vitronectin receptor angiogenesis animal cell animal cell culture animal experiment animal model antineoplastic activity Article Caco-2 cell line CHO cell line chorioallantois colon adenocarcinoma conjugation drug delivery system drug efficacy drug targeting emulsion female human human cell human cell culture in vitro study in vivo study mouse nonhuman physical chemistry sustained drug release tumor vascularization umbilical vein endothelial cell analogs and derivatives animal chemistry drug release drug screening metabolism transport at the cellular level tumor cell line Animals Antineoplastic Agents Biological Transport Cell Line, Tumor Drug Carriers Drug Liberation Humans Integrin alphaVbeta3 Mice Polylactic Acid-Polyglycolic Acid Copolymer Xenograft Model Antitumor Assays
Subjects: QU Biochemistry
QV pharmacology
Divisions: Mashhad University of Medical Sciences
Depositing User: lib2 lib2 lib2
Date Deposited: 09 Jun 2020 05:38
Last Modified: 09 Jun 2020 05:38
URI: http://eprints.mums.ac.ir/id/eprint/17182

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